Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice

Carlos, Félix de; Cobo, Juan; Germanà, G; Silos-Santiago, I.; Laurà, Rosaria; Haro, J. J.; Fariñas, Isabel; Vega, J.A.

doi:10.1016/j.neulet.2006.07.056

Cited by 13 publications

(8 citation statements)

References 17 publications

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“…Nevertheless, the results for BDNF and TrkB are difficult to reconcile with the loss of sensory neurons at 2 weeks. In our hands, Pacinian corpuscles of TrkB deficient mice were largely normal in structure and did not show immunohistochemical TrkB at 15 days (Gonzá lez-Martinez et al, 2004;Perez-Piñ era et al, 2008), although the number of corpuscles was reduced in heterozygotic TrkB deficient mice, and hypoplasic or atrophic in the homozygotic TrkB deficient ones (de Carlos et al, 2006).…”

Section: Development Of Meissner and Pacinianmentioning

confidence: 54%

“…Conversely, overexpression of some neurotrophins in the target organs of specific neurons leads to an increase in the density of corpuscles without affecting the number of neurons in DRG, which suggest that local factors are involved in the development of sensory corpuscles. These approaches allowed the classification of specific subtypes of cutaneous, hair associated or muscular mechanoreceptors according to the neuronal classes on which they depend (Botchkarev et al, 1999;Cronk et al, 2002;de Carlos et al, 2006;Ernfors et al, 1994a,b;Fariñ as et al, 1994;Fundin et al, 1997;Gonzalez-Martinez et al, 2004Ichikawa et al, 2000Ichikawa et al, , 2001Krimm et al, 2006;LeMaster et al, 1999;Matsuo et al, 2001;Pérez-Piñ era et al, 2008;Sedy et al, 2004).…”

Section: Development Of Meissner and Pacinianmentioning

confidence: 99%

See 1 more Smart Citation

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Vega

García‐Suárez

Montano

et al. 2008

Microscopy Res & Technique

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This article reviews the biochemical, physiological, and experimental data cumulated during the last decade on the Meissner and Pacinian corpuscles. It includes information about (i) the localization of molecules recently detected in sensory corpuscles; (ii) the unsolved problem of the accessory fibers in sensory corpuscles and the occurrence of myelin within them; (iii) the development of sensory corpuscles, especially their neuronal and growth factor dependency; (iv) the composition and functional significance of the extracellular matrix as an essential part of the mechanisms involved in the genesis of the stimuli generated in sensory corpuscles; (v) the molecular basis of mechanotransduction; (vi) a miscellaneous section containing sparse new data on the protein composition of sensory corpuscles, as well as in the proteins involved in live-death cell decisions; (vii) the changes in sensory corpuscles as a consequence of aging, the central, or peripheral nervous system injury; and finally, (viii) the special interest of Meissner corpuscles and Pacinian corpuscles for pathologists for the diagnosis of some peripheral neuropathies and neurodegenerative diseases.

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Section: Development Of Meissner and Pacinianmentioning

confidence: 54%

Section: Development Of Meissner and Pacinianmentioning

confidence: 99%

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Vega

García‐Suárez

Montano

et al. 2008

Microscopy Res & Technique

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“…BDNF has been shown to directly attract neurites of a variety of central and peripheral neurons in vitro [23][24][25][26][27][28] . However, neurotrophic factors also promote neuronal survival [29,30] , regulate synaptic communication [31] , induce apoptosis in nonneuronal cells [32] , and influence differentiation in a variety of systems [33,34] . Perturbations in pathfinding arising from altering the levels of a pleiotropic cue could be indirect, via nonneuronal targets of the cue, or could result from the suspected cue altering the ability of the growth cone to respond to the actual guidance molecule (e.g.…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Attracts Geniculate Ganglion Neurites during Embryonic Targeting

Hoshino

Vatterott²,

Egwiekhor³

et al. 2010

Dev Neurosci

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Geniculate axons are initially guided to discrete epithelial placodes in the lingual and palatal epithelium that subsequently differentiate into taste buds. In vivo approaches show that brain-derived neurotrophic factor (BDNF) mRNA is concentrated in these placodes, that BDNF is necessary for targeting taste afferents to these placodes, and that BDNF misexpression disrupts guidance. We used an in vitro approach to determine whether BDNF may act directly on geniculate axons as a trophic factor and as an attractant, and whether there is a critical period for responsiveness to BDNF. We show that BDNF promotes neurite outgrowth from geniculate ganglion explants dissected from embryonic day (E) 15, E18, infant, and adult rats cultured in collagen gels, and that there is a concentration optimum for neurite extension. Gradients of BDNF derived from slow-release beads caused the greatest bias in neurite outgrowth at E15, when axons approach the immature gustatory papillae. Further, neurites advanced faster toward the BDNF bead than away from it, even if the average amount of neurotrophic factor encountered was the same. We also found that neurites that contact BDNF beads did not advance beyond them. At E18, when axons would be penetrating pregustatory epithelium in vivo, BDNF continued to exert a tropic effect on geniculate neurites. However, at postnatal and adult stages, the influence of BDNF was predominantly trophic. Our data support a role for BDNF acting as an attractant for geniculate axons during a critical period that encompasses initial targeting but not at later stages.

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“…We have observed in trkB2/2;trkC1/2 mice a reduction of 18% in the number of Pacinian corpuscles at 25 days and approximately a quarter of the surviving Pacinian corpuscles are hypoplasic or atrophic in these animals (De Carlos et al, 2006). This can be explained on the basis of the neuronal dependence of corpuscle development, since neuronal loss in DRG of mice deficient in TrkB occurs at the second postnatal week (Klein et al, 1993;Silos-Santiago et al, 1997).…”

Section: Local and Neuronal Effects In The Development Of Sensory Cormentioning

confidence: 80%

“…The deficits were larger in NT3 than TrkC mutants and comparable to deficits observed in TrkB or TrkA mutants (Sedy et al, 2004). Another study from our group (De Carlos et al, 2006) showed that Pacinian corpuscles were always present in TrkB (reduction of 13%) or TrkC (reduction 2%) deficient mice. The remaining Pacinian corpuscles showed their typical morphology and immunohistochemical profile but a subset were hypoplasic or atrophic (23% in trkB2/2; trkC1/2 mice; 3% in TrkB1/2; TrkC2/2 mice).…”

Section: Sensory Corpusclesmentioning

confidence: 87%

Development and neuronal dependence of cutaneous sensory nerve formations: Lessons from neurotrophins

Montano

Pérez-Piñera

García‐Suárez

et al. 2009

Microscopy Res & Technique

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Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify the neuronal dependence of each type of cutaneous sensory nerve ending from a concrete subtype of sensory neuron, since the development, maintenance, and structural integrity of sensory nerve formations depend upon sensory neurons. Results obtained from these mouse strains suggest that TrkA positive neurons are connected to intraepithelial nerve fibers and other sensory nerve formations depending from C and Adelta nerve fibers; the neurons expressing TrkB and responding to BDNF and NT-4 innervate Meissner corpuscles, a subpopulation of Merkell cells, some mechanoreceptors of the piloneural complex, and the Ruffini's corpuscles; finally, a subpopulation of neurons, which are responsive to NT-3, support postnatal survival of some intraepithelial nerve fibers and Merkel cells in addition to the muscle mechanoreceptors. On the other hand, changes in NTs and NTRs affect the structure of non-nervous structures of the skin and are at the basis of several cutaneous pathologies. This review is an update about the role of NTs and NTRs in the maintenance of normal cutaneous innervation and maintenance of skin integrity.

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Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice

Cited by 13 publications

References 17 publications

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Brain-Derived Neurotrophic Factor Attracts Geniculate Ganglion Neurites during Embryonic Targeting

Development and neuronal dependence of cutaneous sensory nerve formations: Lessons from neurotrophins

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