Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder

Ghamari, Melina; Mehrab Mohseni, Mahdieh; Taheri, Mohammad; Neishabouri, Seyedeh Morvarid; Shirvani-Farsani, Zeinab

doi:10.1007/s11011-023-01316-1

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…In addition to miRNAs, lncRNAs are also a class of possible biomarkers for air pollution-related mental disorders [148][149][150]. LncRNAs can bind to DNA, RNA, and protein to exert many functions [148].…”

Section: Non-coding Rnasmentioning

confidence: 99%

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Bai,

Wang,

Liu

et al. 2024

Toxics

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Air pollution is one of the greatest environmental risks to health, with 99% of the world’s population living where the World Health Organization’s air quality guidelines were not met. In addition to the respiratory and cardiovascular systems, the brain is another potential target of air pollution. Population- and experiment-based studies have shown that air pollution may affect mental health through direct or indirect biological pathways. The evidence for mental hazards associated with air pollution has been well documented. However, previous reviews mainly focused on epidemiological associations of air pollution with some specific mental disorders or possible biological mechanisms. A systematic review is absent for early effect biomarkers for characterizing mental health hazards associated with ambient air pollution, which can be used for early warning of related mental disorders and identifying susceptible populations at high risk. This review summarizes possible biomarkers involved in oxidative stress, inflammation, and epigenetic changes linking air pollution and mental disorders, as well as genetic susceptibility biomarkers. These biomarkers may provide a better understanding of air pollution’s adverse effects on mental disorders and provide future research direction in this arena.

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Section: Non-coding Rnasmentioning

confidence: 99%

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Bai,

Wang,

Liu

et al. 2024

Toxics

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show abstract

“…LncRNAs are master regulators of gene expression, functioning by regulating transcription, splicing, chromosome looping, chromatin modification, mRNA decay, as well as the regulation of miRNA in normal and disease states [25][26][27][28]. Levels of lncRNA detected in bodily fluids, such as blood, saliva and urine, are shown to be indicative of disease states and are suggested as biomarkers for cancer, bipolar disorder and COVID-19 [29][30][31][32][33][34]. The advantages of using lncRNA as biomarkers include their abundance and stability in body fluids, specificity to a disease, detectability using common molecular biology methods and reproducible quantitative results [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Patel,

Krause-Hauch,

Kenney

et al. 2024

IJMS

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More than 75% of traumatic brain injuries (TBIs) are mild (mTBI) and military service members often experience repeated combat-related mTBI. The chronic comorbidities concomitant with repetitive mTBI (rmTBI) include depression, post-traumatic stress disorder or neurological dysfunction. This study sought to determine a long noncoding RNA (lncRNA) expression signature in serum samples that correlated with rmTBI years after the incidences. Serum samples were obtained from Long-Term Impact of Military-Relevant Brain-Injury Consortium Chronic Effects of Neurotrauma Consortium (LIMBIC CENC) repository, from participants unexposed to TBI or who had rmTBI. Four lncRNAs were identified as consistently present in all samples, as detected via droplet digital PCR and packaged in exosomes enriched for CNS origin. The results, using qPCR, demonstrated that the lncRNA VLDLR-AS1 levels were significantly lower among individuals with rmTBI compared to those with no lifetime TBI. ROC analysis determined an AUC of 0.74 (95% CI: 0.6124 to 0.8741; p = 0.0012). The optimal cutoff for VLDLR-AS1 was ≤153.8 ng. A secondary analysis of clinical data from LIMBIC CENC was conducted to evaluate the psychological symptom burden, and the results show that lncRNAs VLDLR-AS1 and MALAT1 are correlated with symptoms of depression. In conclusion, lncRNA VLDLR-AS1 may serve as a blood biomarker for identifying chronic rmTBI and depression in patients.

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Up‐regulation of HOXA‐AS2 and MEG3 long non‐coding RNAs acts as a potential peripheral biomarker for bipolar disorder

Hosseini,

Mokhtari

2024

J Cellular Molecular Medi

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Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA‐AS2 and MEG3 ncRNA transcripts. HOXA‐AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real‐time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA‐AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA‐AS2 and MEG3 compared to controls. The lncRNAs HOXA‐AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA‐AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA‐AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA‐AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD.

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Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder

Cited by 4 publications

References 38 publications

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Up‐regulation of HOXA‐AS2 and MEG3 long non‐coding RNAs acts as a potential peripheral biomarker for bipolar disorder

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