Abstract:This study demonstrated impaired FMD in patients with NTG and the results provide evidence of a generalized peripheral vascular endothelial dysfunction in patients with NTG.
“…It is often used to determine cardiovascular disease risk factors in cardiovascular research (Anderson et al, 2000), but more recently has also been adopted in ophthalmological studies to investigate peripheral vascular endothelial functionality in glaucoma patients (Su et al, 2008), in NTG (Su et al, 2006) and pseudoexfoliative syndrome (Atalar et al, 2006).…”
The increase of ET-1 in POAG patients is related to vascular dysfunction (r=0.942; p=0.001) and vascular dysfunction is related to sub-clinical intraocular inflammation (r=0.968; p=0.001). Thus ET-1 and vascular dysfunction related to sub-clinical inflammation may play a key role in determining a progressive visual field damage in POAG patients who present a well-controlled IOP.
“…It is often used to determine cardiovascular disease risk factors in cardiovascular research (Anderson et al, 2000), but more recently has also been adopted in ophthalmological studies to investigate peripheral vascular endothelial functionality in glaucoma patients (Su et al, 2008), in NTG (Su et al, 2006) and pseudoexfoliative syndrome (Atalar et al, 2006).…”
The increase of ET-1 in POAG patients is related to vascular dysfunction (r=0.942; p=0.001) and vascular dysfunction is related to sub-clinical intraocular inflammation (r=0.968; p=0.001). Thus ET-1 and vascular dysfunction related to sub-clinical inflammation may play a key role in determining a progressive visual field damage in POAG patients who present a well-controlled IOP.
“…29,[31][32][33] The results about plasma hsCRP levels in normal tension glaucoma are controversial. Su et al 16 reported no difference in the hsCRP level between normal tension glaucoma and controls after exclusion of patients with cardiovascular and other systemic diseases and they suggested that systemic vascular inflammation may not be a major cause in pathogenesis of glaucoma.…”
Our findings indicated no difference in the hsCRP level between XFS, XFG, and controls. This study suggests that CRP is not a predictive marker of inflammation and peripheral endothelial dysfunction in XFS, which is accepted as a systemic disorder.
“…It should be considered that there could be intra-observer differences in measurements. However, previous studies showed that intra-observed differences are minimal without significant effect on results [9,10]. In our study, an experienced cardiologist performed measurements.…”
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