Abnormal Functional Asymmetry in the Salience and Auditory Networks in First-episode, Drug-naive Somatization Disorder

Su, Qinji; Yu, Miaoyu; Liu, Feng; Li, Yaping; Dong-lian, LI; Deng, Meijiao; Lu, Jiongmin; Wu, Cailian; Guo, Wenbin

doi:10.1016/j.neuroscience.2020.07.043

Cited by 7 publications

(4 citation statements)

References 52 publications

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“…The communication and coordination between two hemispheres are of great significance for efficient process of complex and complementary cognitive tasks ( Hoptman and Davidson, 1994 ; Güntürkün et al, 2020 ). PAS has been applied in exploring the anomalous asymmetry in many psychiatric disorders ( Zhu et al, 2018 , 2019 ; Su et al, 2020 ; Ding et al, 2021 ; Jia et al, 2021 ). In the present study, we investigated functional asymmetry in MDD patients with concomitant GI symptoms with this novel approach.…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms

Ding

Chen

et al. 2022

Front. Neurosci.

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ObjectiveDisrupted brain functional asymmetry has been reported in major depressive disorder (MDD). The comorbidity may be a crucial factor to this functional asymmetry. It is quite common that gastrointestinal (GI) symptoms are comorbid with MDD, but limited evidence focuses on the effect of GI comorbidity on the neuropathology of MDD from a functional lateralization perspective.MethodsResting-state functional magnetic resonance imaging was obtained in 28 healthy controls (HCs), 35 MDD patients with GI symptoms (GI-MDD patients), and 17 patients with MDD without GI symptoms (nGI-MDD patients). The parameter of asymmetry (PAS) was used to analyze the imaging data and evaluate the changes of functional asymmetry.ResultsThe GI-MDD patients showed increased PAS scores in the left inferior frontal gyrus (IFG) and superior medial prefrontal cortex (MPFC) and decreased PAS scores in the right postcentral gyrus in comparison with nGI-MDD patients. The PAS scores of the left IFG and left superior MPFC were correlated with the severity of GI problems and could be applied to distinguish GI-MDD patients from nGI-MDD patients with an accuracy, a sensitivity, and a specificity of 92.31, 100, and 76.47%, respectively. Furthermore, GI-MDD and nGI-MDD patients both displayed increased PAS scores in the PCC/precuneus.ConclusionsThis study revealed the influence of concomitant GI symptoms on functional asymmetry in MDD patients. Increased PAS scores of the left IFG and superior MPFC might represent an unbalanced regulation of brain over GI function and had the potential to be regarded as distinctive features related to functional GI symptoms in MDD.

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Section: Introductionmentioning

confidence: 99%

Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms

Ding

Chen

et al. 2022

Front. Neurosci.

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“…The change of network homogeneity (NH) is used to explain the aberrant connectivity of the default mode network (DMN) in patients with depression or lTLE ( 21 , 22 ) and also to explain alterations in the dorsal attachment network (DAN) and the ventral attachment network (VAN) in patients with rTLE ( 23 , 24 ). Functional connectivity (FC) is often used as a neuroimaging biomarker when assessing intrahemispheric and interhemispheric salience and auditory network abnormalities in patients with somatization disorders ( 25 ). Degree centrality (DC) has also been leveraged as an imaging biomarker to aid in rTLE diagnosis ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses

Chu

Wei

et al. 2022

Front. Psychiatry

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BackgroundPrior reports revealed abnormalities in voxel-mirrored homotopic connectivity (VMHC) when analyzing neuroimaging data from patients with various psychiatric conditions, including temporal lobe epilepsy (TLE). Whether these VHMC changes can be leveraged to aid in the diagnosis of right TLE (rTLE), however, remains to be established. This study was thus developed to examine abnormal VMHC findings associated with rTLE to determine whether these changes can be used to guide rTLE diagnosis.MethodsThe resultant imaging data of resting-state functional MRI (rs-fMRI) analyses of 59 patients with rTLE and 60 normal control individuals were analyzed using VMHC and support vector machine (SVM) approaches.ResultsRelative to normal controls, patients with rTLE were found to exhibit decreased VMHC values in the bilateral superior and the middle temporal pole (STP and MTP), the bilateral middle and inferior temporal gyri (MTG and ITG), and the bilateral orbital portion of the inferior frontal gyrus (OrbIFG). These patients further exhibited increases in VMHC values in the bilateral precentral gyrus (PreCG), the postcentral gyrus (PoCG), and the supplemental motor area (SMA). The ROC curve of MTG VMHC values showed a great diagnostic efficacy in the diagnosis of rTLE with AUCs, sensitivity, specificity, and optimum cutoff values of 0.819, 0.831, 0.717, and 0.465. These findings highlight the value of the right middle temporal gyrus (rMTG) when differentiating between rTLE and control individuals, with a corresponding SVM analysis yielding respective accuracy, sensitivity, and specificity values of 70.59% (84/119), 78.33% (47/60), and 69.49% (41/59).ConclusionIn summary, patients with rTLE exhibit various forms of abnormal functional connectivity, and SVM analyses support the potential value of abnormal VMHC values as a neuroimaging biomarker that can aid in the diagnosis of this condition.

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“…Healthy individuals can benefit from normal asymmetries. However, the asymmetries are disrupted in some mental disorders, such as schizophrenia ( Federspiel et al, 2006 ), attention-deficit/hyperactivity disorder ( Shaw et al, 2009 ), somatization disorder ( Su et al, 2020 ), and autism ( Herbert et al, 2005 ). Patients with obsessive-compulsive disorder (OCD) also displayed anomalous brain asymmetries ( Boedhoe et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…PAS is a voxel-wise approach that is unaffected by preselected regions of interest (ROIs) and thresholds, thus minimizing the potential confounding effects of structural asymmetries and selection bias through ROIs ( Zhu et al, 2018 ). It has been widely used in exploring inter- and/or intra-hemispheric asymmetries in patients with schizophrenia and their unaffected siblings, individuals at ultra-high risk for psychosis, major depressive disorder ( Ding et al, 2021 ), and somatization disorder ( Zhu et al, 2018 , 2019 ; Su et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder

Jia

Chen

et al. 2021

Front. Neurosci.

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Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale–Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs.

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Abnormal Functional Asymmetry in the Salience and Auditory Networks in First-episode, Drug-naive Somatization Disorder

Cited by 7 publications

References 52 publications

Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms

Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms

Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder

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