Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease

Lévy, Émile; Brunet, Sylvain; Alvarez, Fernando; Seidman, Ernest G.; Bouchard, Guylaine; Escobar, Enrique; Martin, Spencer D.

doi:10.1016/j.lfs.2007.01.017

Cited by 37 publications

(32 citation statements)

References 58 publications

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“…TG, LDLc and HDLc values were within the reference ranges observed in other studies [14,15], whereas CHOL concentrations were increased in all the groups compared to that observed by Levy et al [14]. …”

Section: Resultssupporting

confidence: 84%

Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

et al. 2013

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BackgroundHigh consumption of fish carries a lower risk of cardiovascular disease as a consequence of dietary omega-3 long chain polyunsaturated fatty acid (n-3 PUFA; especially EPA and DHA) content. A controversy exists about the component/s responsible of these beneficial effects and, in consequence, which is the best proportion between both fatty acids. We sought to determine, in healthy Wistar rats, the proportions of EPA and DHA that would induce beneficial effects on biomarkers of oxidative stress, and cardiovascular disease risk.MethodsFemale Wistar rats were fed for 13 weeks with 5 different dietary supplements of oils; 3 derived from fish (EPA/DHA ratios of 1:1, 2:1, 1:2) plus soybean and linseed as controls. The activities of major antioxidant enzymes (SOD, CAT, GPX, and GR) were determined in erythrocytes and liver, and the ORAC test was used to determine the antioxidant capacity in plasma. Also measured were: C reactive protein (CRP), endothelial dysfunction (sVCAM and sICAM), prothrombotic activity (PAI-1), lipid profile (triglycerides, cholesterol, HDLc, LDLc, Apo-A1, and Apo-B100), glycated haemoglobin and lipid peroxidation (LDL-ox and MDA values).ResultsAfter three months of nutritional intervention, we observed statistically significant differences in the ApoB100/ApoA1 ratio, glycated haemoglobin, VCAM-1, SOD and GPx in erythrocytes, ORAC values and LDL-ox. Supplementation with fish oil derived omega-3 PUFA increased VCAM-1, LDL-ox and plasma antioxidant capacity (ORAC). Conversely, the ApoB100/ApoA1 ratio and percentage glycated haemoglobin decreased.ConclusionsOur results showed that a diet of a 1:1 ratio of EPA/DHA improved many of the oxidative stress parameters (SOD and GPx in erythrocytes), plasma antioxidant capacity (ORAC) and cardiovascular risk factors (glycated haemoglobin) relative to the other diets.

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Section: Resultssupporting

confidence: 84%

Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

et al. 2013

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“…A marked effect of elevated copper on lipid metabolism was also reported in Long-Evans Cinnamon (LEC) rat, another murine model of WD (86). Analysis of the liver and serum lipid profiles in these animals showed that copper overload was associated with a higher content of triglycerides, free cholesterol and cholesteryl ester when compared to controls.…”

Section: Copper Overload In Wilson's Disease Markedly Alters Lipid Mementioning

confidence: 74%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

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“…3D), given the well-known involvement of this enzyme in ALD-associated oxidative stress21. The downregulation of cholesterol 7α-hydroxylase (CYP7A1) may also be related to the formation of LOOHs and MDBs, since this enzyme is also downregulated in a rat model of Wilson disease22, another liver disorder characterized by the presence of MDBs and LOOHs.…”

Section: Resultsmentioning

confidence: 99%

Gender Dimorphic Formation of Mouse Mallory–Denk Bodies and the Role of Xenobiotic Metabolism and Oxidative Stress

et al. 2010

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Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease

Cited by 37 publications

References 58 publications

Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

The Role of Copper as a Modifier of Lipid Metabolism

Gender Dimorphic Formation of Mouse Mallory–Denk Bodies and the Role of Xenobiotic Metabolism and Oxidative Stress

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