Abnormal Large-Scale Neuronal Network in High Myopia

Abstract

AimResting state functional magnetic resonance imaging (rs-fMRI) was used to analyze changes in functional connectivity (FC) within various brain networks and functional network connectivity (FNC) among various brain regions in patients with high myopia (HM).Methodsrs-fMRI was used to scan 82 patients with HM (HM group) and 59 healthy control volunteers (HC group) matched for age, sex, and education level. Fourteen resting state networks (RSNs) were extracted, of which 11 were positive. Then, the FCs and FNCs of RSNs in HM patients were examined by independent component analysis (ICA).ResultsCompared with the HC group, FC in visual network 1 (VN1), dorsal attention network (DAN), auditory network 2 (AN2), visual network 3 (VN3), and sensorimotor network (SMN) significantly increased in the HM group. FC in default mode network 1 (DMN1) significantly decreased. Furthermore, some brain regions in default mode network 2 (DMN2), default mode network 3 (DMN3), auditory network 1 (AN1), executive control network (ECN), and significance network (SN) increased while others decreased. FNC analysis also showed that the network connection between the default mode network (DMN) and cerebellar network (CER) was enhanced in the HM group.ConclusionCompared with HCs, HM patients showed neural activity dysfunction within and between specific brain networks, particularly in the DMN and CER. Thus, HM patients may have deficits in visual, cognitive, and motor balance functions.

Abnormal static and dynamic functional network connectivity in stable chronic obstructive pulmonary disease

“…The ICA is an advanced data-driven approach, which evaluates the whole brain data and then separate it into individual components, enabling us to conduct in-depth observational studies of brain connectivity ( van den Heuvel et al, 2009 ; Vargas et al, 2013 ). Some previous studies have already applied it to some related diseases, such as acute thyrotoxic myopathy ( Li et al, 2022 ), attention deficit and hyperactivity disorder ( Kumar et al, 2021 ), juvenile absence epilepsy ( Parsons et al, 2020 ), high myopia ( Ji et al, 2022 ), and so on. Our brains must dynamically integrate, coordinate, and respond to all internal and external stimuli so that we could feel, remember, think, and correlate with others ( Hutchison et al, 2013 ).…”

Exploration of Hippocampal Functional Connectivity Alterations in Patients with High Myopia via Seed-Based Functional Connectivity Analysis

“…Consequently, patients with HM may exhibit deficits in visual, motor, and cognitive functions. 15 Zhang demonstrated that patients with HM show variations in amplitude of low-frequency fluctuations (ALFF) and DMN across different brain regions, which might signify cognitive changes associated with HM. 16 Moreover, other studies have indicated that myopia patients are nearly twice as likely to develop cognitive impairment compared to individuals with refractive errors.…”