Abnormal levels of the α chain of the CD22 adhesion molecule may account for low CD22 surface expression in chronic lymphocytic leukemia

Payelle-Brogard, Béatrice; Dumas, Gérard; Magnac, Christian; Lalanne, Ana I.; Dighiero, Guillaume; Vuillier, Françoise

doi:10.1038/sj.leu.2404155

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B-cell Receptor Response1

B-cell Receptor (Bcr) Characteristics In Cll1

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Cited by 4 publications

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“…[30] Most B-cell chronic lymphocytic leukemia cells express CD5 and IgM/IgD due to which they have a mantle zone-like phenotype of naive cells that., …, express unmutated immunoglobulin genes normally. [31] Somatic mutations of IGHV genes are seen in Fifty to seventy percent of cases of chronic lymphocytic leukemia., [32] appearing as if they had matured from a lymphoid follicle.…”

Section: B-cell Receptor Responsementioning

confidence: 99%

Recent advances in chronic lymphocytic leukemia

Vyas¹,

Hassan²

2012

Indian J Cancer

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Section: B-cell Receptor Responsementioning

confidence: 99%

Recent advances in chronic lymphocytic leukemia

Vyas¹,

Hassan²

2012

Indian J Cancer

View full text Add to dashboard Cite

“…However, they cannot be assembled and transported from the endoplasmic reticulum to the cell surface because of a folding and glycosolation defect of the mu and CD79a chains though not of the CD79b chain. The poor expression of the CD22 molecule in B-CLL cells, was also found to result as a consequence of a folding defect occurring in its chain [65].…”

Section: B-cell Receptor (Bcr) Characteristics In Cllmentioning

confidence: 99%