Abnormal miRNA-30e Expression is Associated with Breast Cancer Progression

Lin, Ziying; Li, Jianwen; Wang, Yahong; Chen, Ting; Ren, Nina; Yang, Liting; Xu, Wenya; He, Hong; Jiang, Yun; Chen, Xiao; Liu, Tie; Liu, Gang

doi:10.7754/clin.lab.2015.150607

Cited by 23 publications

(14 citation statements)

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“…Among the top 40 predicted miRNAs, 38 miRNAs were confirmed by the three aforementioned databases; and only hsa-mir-30e and hsa-mir-142 were not confirmed. However, Lin et al 44. demonstrated that has-miR-30e were down regulated in both plasma and breast cancer tissues, as described in the literature45, which provided information that has-mir-142 inhibited breast cancer cell invasiveness.…”

Section: Resultsmentioning

confidence: 90%

Network Consistency Projection for Human miRNA-Disease Associations Inference

Liao

et al. 2016

Sci Rep

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Prediction and confirmation of the presence of disease-related miRNAs is beneficial to understand disease mechanisms at the miRNA level. However, the use of experimental verification to identify disease-related miRNAs is expensive and time-consuming. Effective computational approaches used to predict miRNA-disease associations are highly specific. In this study, we develop the Network Consistency Projection for miRNA-Disease Associations (NCPMDA) method to reveal the potential associations between miRNAs and diseases. NCPMDA is a non-parametric universal network-based method that can simultaneously predict miRNA-disease associations in all diseases but does not require negative samples. NCPMDA can also confirm the presence of miRNAs in isolated diseases (diseases without any known miRNA association). Leave-one-out cross validation and case studies have shown that the predictive performance of NCPMDA is superior over that of previous method.

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Section: Resultsmentioning

confidence: 90%

Network Consistency Projection for Human miRNA-Disease Associations Inference

Liao

et al. 2016

Sci Rep

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“…Based on different tumour histopathological types, miR‐30e showed differential expression in different cancer types. It was found down‐regulated in bladder cancer , breast cancer and rectal adenocarcinoma without chemoradiotherapy responsiveness and correlated with the clinical stage and favourable prognosis, indicating the tumour suppressive role in cancer. But, some studies showed that miR‐30e was up‐regulated in malignant salivary gland tumours , LAC involving cancer invasion and metastasis , revealing miR‐30e as the potential diagnostic and prognostic biomarker for the therapy of these malignancies.…”

Section: Introductionmentioning

confidence: 98%

MicroRNA‐30e‐5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma

Shou

et al. 2017

J Cellular Molecular Medi

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Aberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis in multiple diseases including cancers. MicroRNA‐30e‐5p (miR‐30e) was previously reported as an oncogenic or tumour suppressing miRNA in some malignancies, but its function in lung adenocarcinoma (LAC) remains largely undefined. In this study, we found that the expression of miR‐30e was increased in LAC tissues and cell lines, associated with tumour size and represented an independent prognostic factor for overall survival and recurrence of LAC patients. Further functional experiments showed that knockdown of miR‐30e suppressed cell growth while its overexpression promoted growth of LAC cells and xenografts in vitro and in vivo. Mechanistically, PTPN13 was identified as the direct target of miR‐30e in LAC, in which PTPN13 expression was down‐regulated in LAC tissues and showed the inverse correlation with miR‐30e expression. Overexpression of PTPN13 inhibited cell growth and rescued the proliferation‐promoting effect of miR‐30e through inhibition of the EGFR signalling. Altogether, our findings suggest that miR‐30e could function as an oncogene in LAC via targeting PTPN13 and act as a potential therapeutic target for treating LAC.

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“…MicroRNAs (miRNAs) are a class of small (19-24 nucleotides) non-coding functional RNAs, highly conserved and widespread in the whole body. MicroRNA mediates posttranscriptional regulation of gene expression by targeting 3'untranslated regions (3'UTR) of mRNAs, now known to be key players in a variety of biological processes, including development, differentiation, growth, metabolism and tumorigenesis [3][4][5][6]. Increasing evidences confirmed that microRNA plays a crucial role in lung cancer tumorigenesis [7][8][9][10].…”

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confidence: 99%

miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1

Hou¹,

Sun²,

Yu³

et al. 2017

neo

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Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer.

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Abnormal miRNA-30e Expression is Associated with Breast Cancer Progression

Cited by 23 publications

References 0 publications

Network Consistency Projection for Human miRNA-Disease Associations Inference

Network Consistency Projection for Human miRNA-Disease Associations Inference

MicroRNA‐30e‐5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma

miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1

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