Abnormal neural activity in partially remitted late-onset depression: An fMRI study of one-back working memory task

Alteration of spontaneous neuronal activity within the salience network in partially remitted depression

“…The prefrontal cortex, including the inferior frontal gyrus, is thought to play a central role in the cognitive control of behavior (Ochsner and Gross, 2005;Phillips et al, 2003aPhillips et al, , 2003b, while the limbicrelated regions, including the middle temporal gyrus and insula, are thought to be implicated in the appraisal of emotions (Mak et al, 2009;Phan et al, 2002;Phillips et al, 2003aPhillips et al, , 2003b. Our findings are partly consistent with a previous study investigating partially remitted late-onset depression with abnormalities within the cortico-limbic circuits involving the inferior frontal gyrus, supramarginal gyrus, insula, and middle temporal gyrus (Lee et al, 2013). Balance between the prefrontal cortex and limbic-related regions may be modulated by the salience network, including the insular cortex.…”

“…Within the four-phase Sequenced Treatment Alternatives to Relieve Depression (STARnD) study for evaluating various levels of treatment, the remission rates are 37%, 31%, 14%, and 13% from the first to fourth phases, respectively (Rush, 2007). Even worse, lack of complete remission from an acute episode of depression has been associated with a higher relapse rate, more severe depressive episodes, poor prognosis, and risk of suicide events (Fava, 2006;Judd et al, 1997;Judd et al, 2000;Lee et al, 2013). Despite having a tremendous impact on outcomes such as future relapse, morbidity, and mortality, the neural underpinnings of partial remission in depression remain poorly understood at present.…”

“…The only fMRI study that has compared depression with partial remission had a small sample size and studied only older adults (Lee et al, 2013).…”

Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis

“…We identified 32 eligible whole-brain neuroimaging papers comparing LLD patients with HC individuals (Albert, Gau, Taylor, & Newhouse, 2017;Bobb et al, 2012;Bricenõ et al, 2015;Byun et al, 2016;Chen et al, 2012;De Asis et al, 2001;Dombrovski et al, 2013;Dumas & Newhouse, 2015;Fang et al, 2015;Guo et al, 2013;Harada et al, 2018Harada et al, , 2016Hou, Sui, Song, & Yuan, 2016;C. M. Huang et al, 2019;Hwang et al, 2010;Lee, Liu, Wai, Ko, & Lee, 2013;Li et al, 2020;Liu et al, 2012;Mah, Williams, Leung, Freel, & Pollock, 2011;Oudega et al, 2014;Rao et al, 2015;Respino et al, 2019;Ribeiz et al, 2013;Smith, Kramer, et al, 2009;Takami, Okamoto, Yamashita, Okada, & Yamawaki, 2007;Wang et al, 2008;Weisenbach et al, 2014;Wong et al, 2016;Xie et al, 2012;Yuan, Zhu, et al, 2008;Yue, Jia, Hou, Zang, & Yuan, 2015). Among these four groups of papers had (partially) overlapping samples, including (Bricenõ et al, 2015;Rao et al, 2015;Weisenbach et al, 2014), (Chen et al, 2012;Guo et al, 2013;Liu et al, 2012), (Harada et al, 2018(Harada et al, , 2016, and…”

APOE-ε4 Allele Altered the Rest-Stimulus Interactions in Healthy Middle-Aged Adults

“…In middle-aged adults with APOE-ε4 allele, they recruited greater additional resources to compensate for processing inefficiencies in the low-memory load as well as had already recruited most of their (assuming a finite amount) available resources in the moderate- and high-memory loads. However, few studies had focused on the WM activation in the higher memory-load experiments (i.e., 3-back WM task), because these experiments were comparatively difficult for elderly participants [ 44 ].…”