Abnormal P-wave terminal force in lead V1 is associated with low left atrial appendage ejection velocity

McConkey, Nathaniel; Malamas, Peter; Norby, Faye L.; Plamenac, Jovan; Park, R.; Weigel, Frank; González, Mario D.; Naccarelli, Gerald V.; Maheshwari, Ankit

doi:10.1016/j.jelectrocard.2021.06.011

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…21,22 Furthermore, PTFV1 has been associated with low LA appendage ejection velocity on transoesophageal echocardiography. 23 The Cardiovascular Health Study reported PTFV1 to be associated with prevalent magnetic resonance imaging (MRI)-defined infarcts, especially nonlacunar infarcts. 24 The results suggest that PTFV1 may reflect a thromboembolic mechanism that induces ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yang

Jing

et al. 2022

European Stroke Journal

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Introduction: Whether atrial cardiopathy is associated with stroke prognosis remains unclear. We evaluated the association between atrial cardiopathy markers and outcomes in patients with ischemic stroke using a nationwide prospective registry. Patients and methods: Based on the Third China National Stroke Registry, we evaluated different atrial cardiopathy markers including increased P-wave terminal force in V1 (PTFV1), advanced interatrial block (aIAB), prolonged P-wave duration, prolonged P-wave dispersion, paroxysmal supraventricular tachycardia, premature atrial contractions, prolonged PR interval, and severe left atrial enlargement in ischemic stroke patients. The outcomes were death and ischemic stroke recurrence at 1 year. The association between atrial cardiopathy markers and outcomes was analyzed using Cox regression models. Results: At 1-year follow-up, 486 (3.4%) patients had died and 1317 (9.3%) patients had experienced ischemic stroke recurrence. After adjustment for clinical risk factors including atrial fibrillation, PTFV1 > 5000 μV·ms (adjusted hazard ratio [HR] 1.70, 95% confidence interval [CI]: 1.18–2.45, p = 0.004) and aIAB (adjusted HR 1.47, 95% CI: 1.14–1.91, p = 0.003) were significantly associated with mortality. PTFV1 > 5000 μV·ms was significantly associated with ischemic stroke recurrence (adjusted HR 1.54, 95% CI: 1.22–1.96, p = 0.0004). This association was observed although we excluded patients diagnosed with atrial fibrillation. Discussion and Conclusion: Atrial cardiopathy markers, especially PTFV1 and aIAB, are significantly associated with a higher risk of poor prognosis in patients with ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yang

Jing

et al. 2022

European Stroke Journal

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“…Abnormal PTFV1 is also associated with functional remodeling. First, it is associated with low LA appendage ejection velocity in transesophageal echocardiography ( 36 ). Second, LA strain measured by speckle tracking echocardiography as a marker of functional atrial remodeling is significantly reduced in the presence of an abnormal PTFV1 ( 37 ).…”

Section: Electrocardiographymentioning

confidence: 99%

Left Atrial Cardiomyopathy – A Challenging Diagnosis

Kreimer

Gotzmann

2022

Front. Cardiovasc. Med.

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Left atrial cardiomyopathy (LACM) has been an ongoing focus of research for several years. There is evidence that LACM is responsible for atrial fibrillation and embolic strokes of undetermined sources. Therefore, the correct diagnosis of LACM is of clinical importance. Various techniques, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, computed tomography, electroanatomic mapping, genetic testing, and biomarkers, can both identify and quantify structural, mechanical as well as electrical dysfunction in the atria. However, the question arises whether these techniques can reliably diagnose LACM. Because of its heterogeneity, clinical diagnosis is challenging. To date, there are no recommendations for standardized diagnosis of suspected LACM. However, standardization could help to classify LACM more precisely and derive therapeutic directions to improve individual patient management. In addition, uniform diagnostic criteria for LACM could be important for future studies. Combining several parameters and relating them seems beneficial to approach the diagnosis of LACM. This review provides an overview of the current evidence regarding the diagnosis of LACM, in which several potential parameters are discussed and, consequently, a proposal for a diagnostic algorithm is presented.

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Comparison of P-wave parameter changes after radiofrequency ablation and cryoballoon ablation for paroxysmal atrial fibrillation: An observational cohort study

Antoun,

Li,

Vali

et al. 2025

Journal of Electrocardiology

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Abnormal P-wave terminal force in lead V1 is associated with low left atrial appendage ejection velocity

Cited by 4 publications

References 44 publications

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Left Atrial Cardiomyopathy – A Challenging Diagnosis

Comparison of P-wave parameter changes after radiofrequency ablation and cryoballoon ablation for paroxysmal atrial fibrillation: An observational cohort study

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