Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

Eghtedarian, Reyhane; Ghafouri‐Fard, Soudeh; Bouraghi, Hamid; Hussen, Bashdar Mahmud; Arsang‐Jang, Shahram; Taheri, Mohammad

doi:10.1186/s12888-022-03811-8

Cited by 9 publications

(10 citation statements)

References 30 publications

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“…Further experiments have shown upregulation of VDR, MALAT1 and LINC00511 in breast tumors relative to nearby non-cancerous samples, and associations between clinicopathological data and expression of VDR-associated lncRNAs [ 48 ]. These lncRNAs have also been examined in Parkinson's disease [ 49 ], bipolar disorder [ 50 ], schizophrenia [ 51 ], and epilepsy [ 52 ].…”

Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

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A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders. Numerous human conditions and diseases stem from gene-environment interactions; in this regard, a wealth of reports demonstrate that the intake of specific and essential nutrients, including vitamins, shapes our transcriptome, with corresponding impacts on health. Vitamins command a vast array of biological activities, acting as coenzymes, antioxidants, hormones, and regulating cellular proliferation and coagulation. Emerging evidence suggests that vitamins and lncRNAs are interconnected through several regulatory axes. This type of interaction is expected, since lncRNA has been implicated in sensing the environment in eukaryotes, conceptually similar to riboswitches and other RNAs that act as molecular sensors in prokaryotes. In this review, we summarize the peer-reviewed literature to date that has reported specific functional linkages between vitamins and lncRNAs, with an emphasis on mammalian models and humans, while providing a brief overview of the source, metabolism, and function of the vitamins most frequently investigated within the context of lncRNA molecular mechanisms, and discussing the published research findings that document specific connections between vitamins and lncRNAs.

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Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

Self Cite

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“… 38 Because vitamin D receptor polymorphisms also contribute to bipolar disorder, gene polymorphisms may influence both neuroaxonal integrity and the effects of vitamin D on brain function in bipolar disorder. 39 Future longitudinal studies are required to investigate potential temporal associations between these factors. We also analysed the association between vitamin D, NfL levels and the interaction and clinical variables, such as clinical course and DDD, for each pharmacological category.…”

Section: Discussionmentioning

confidence: 99%

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

Chen

Huang²,

Chiu³

et al. 2022

BJPsych open

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Background Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear. Aims To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder. Method Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified by age groups and used general linear models to identify associations between vitamin D and NfL levels and their interaction effects on cognitive domains. Results The mean vitamin D and NfL levels were 16.46 ng/nL and 11.10 pg/mL, respectively; 72% of patients were vitamin D deficient. In the older group, more frequent hospital admissions and lower physical activity were identified in the group with versus without vitamin D deficiency. The age-modified interaction effect of vitamin D and NfL was associated with composite neurocognitive scores and verbal fluency in both age groups, and with processing speed domain in the younger group. Conclusions We observed a high vitamin D deficiency prevalence in bipolar disorder. We identified the interaction of vitamin D and NfL on cognitive domains, and the effect was modified by age. Longitudinal or randomised controlled studies enrolling patients with various illness durations and mood statuses are required to validate our findings.

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“…The results showed higher VDR expression in both dlPFC and ACC in suicides relative to controls [ 99 ]. Another study also reported an upregulation of the VDR gene in bipolar disorder, and it correlated with an elevated risk of premature death from suicide and comorbid conditions [ 116 ]. These changes in the VDR gene expression could be associated to genetic variants or epigenetic factors.…”

Section: Relationship Between Vdr Gene Depression ...mentioning

confidence: 99%

Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk

Somoza-Moncada

Turrubiates-Hernández

Muñoz‐Valle

et al. 2023

Nutrients

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Suicide is one of the leading causes of death worldwide. According to the World Health Organization (WHO), every year, more than 700 thousand people die from this cause. Therefore, suicide is a public health issue. The complex interaction between different factors causes suicide; however, depression is one of the most frequent factors in people who have attempted suicide. Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. The present narrative review shows the potential pathogenic role of vitamin D deficiency in depression and suicide and the potential benefits of vitamin D supplementation to reduce their risk.

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Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

Cited by 9 publications

References 30 publications

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk

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