Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study

Meyer, Ellen; Westerveld, H. T.; Ruyter-Meijstek, Florianne C. de; Greevenbroek, Marleen M.J. van; Rienks, Rienk; Rijn, H. J. M. Van; Erkelens, D. W.; Bruin, T.W.A. de

doi:10.1016/0021-9150(96)05832-7

Cited by 108 publications

(69 citation statements)

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“…Peak and late postprandial triglyceride concentrations have been associated with coronary atherosclerosis [7,26,27] and early carotid atherosclerosis [8,28]. Furthermore, postprandial retinyl palmitate concentrations, reflecting postprandial concentrations of chylomicrons and chylomicron remnants, are associated with CHD in case-control studies [29,30] and postprandial plasma concentrations of small chylomicron remnants are related to progression of coronary lesions as determined by sequential coronary angiographies [31].…”

Section: Discussionmentioning

confidence: 99%

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

et al. 2000

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A cluster of risk factors for Type II (non-insulin-dependent) diabetes mellitus and cardiovascular disease, called the metabolic syndrome, is a common feature of otherwise healthy people living in industrialised countries. Increased visceral adipose tissue depots, insulin resistance with ensuing hyperinsulinaemia and dyslipoproteinaemia including hypertriglyceridaemia, a low HDL cholesterol concentration and a preponderance of small, dense LDL particles are central components of this syndrome [1]. The links between glucose-insulin homeostasis and lipoprotein metabolism have received particular atten- Abstract Aims/hypothesis. Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-aged men. Methods. The subjects, 99 healthy 50-year-old men with an apolipoprotein E3/3 genotype, ate a mixed meal. The apolipoprotein B-48 and B-100 contents were determined in triglyceride-rich lipoproteins as a measure of chylomicron remnant and very low density lipoprotein particle concentrations. Results. Fasting plasma insulin was associated with the triglyceride response to the test meal, independently of body mass index, waist-to-hip circumference ratio, blood glucose and the insulin effect on fasting plasma triglycerides. Exaggerated and prolonged postprandial lipaemia in subjects in the upper quartile of the plasma insulin distribution was largely accounted for by large (Svedberg flotation rate > 60) very low density lipoproteins and chylomicron remnants. Insulin relations to large postprandial triglyceride-rich lipoproteins exclusively reflected the association between plasma insulin and the fasting plasma concentrations of these lipoprotein species, whereas plasma insulin and late postprandial plasma concentrations of small (Svedberg flotation rate 20±60) chylomicron remnants were related, independently of insulin influences on fasting concentrations. Strong positive relations were found between the late increases in large triglyceride-rich lipoproteins and plasma non-esterified fatty acid concentrations after 6 h. Conclusion/interpretation. The degree of insulin sensitivity is a major determinant of postprandial lipaemia in healthy middle-aged men and could add to the regulation of the basal production of large triglyceride-rich lipoproteins. [Diabetologia (2000)

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Section: Discussionmentioning

confidence: 99%

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

et al. 2000

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“…Fasting apo B-48 levels are correlated with postprandial TG increase 19) and are significantly higher in patients with accumulated CM and CM remnants 17) and metabolic syndrome (MetS) 20) . High fasting apo B-48 levels are correlated with premature carotid artery stenosis 21,22) , and postprandial increases in TG and apo B-48 are correlated with CHD 23) . Emerging evidence has suggested that CM remnants are responsible for the initiation and development of atherosclerotic plaques in vitro and in vivo 2) .…”

Section: Subjects and Patientsmentioning

confidence: 99%

Apolipoprotein B-48 to Triglyceride Ratio Is a Novel and Useful Marker for Detection of Type III Hyperlipidemia after Antihyperlipidemic Intervention

Yuasa-Kawase

Masuda

Kitazume-Taneike

et al. 2012

JAT

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“…Lipid enriched enteral solutions or meals with a high fat and caloric content are used for lipid loading in literature (17)(18)(19)(20)(21). Since it is well tolerated by the patients and easily provided in our country we preferred to give a breakfast rich in lipids.…”

Section: Lipid Loading Protocolmentioning

confidence: 99%

“…Postprandial hypertriglyceridemia, reflecting an elevated concentration of lipoprotein remnant particles, might change atherosclerotic lesion content and might show procoagulant, anti-fibrinolytic and pro-inflammatory effects (7,8). Previously some prospective studies (9)(10)(11)(12)(13)(14)(15)(16) and case-control studies (17)(18)(19)(20)(21) demonstrated a relationship between nonfasting triglyceride levels and cardiovascular disease. These case-control studies used different fat loading protocols in different patient groups and conflicting results were found.…”

Section: Introductionmentioning

confidence: 99%

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

Atar¹,

Atar²,

Aydınalp³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Biz bu çalışmada, tokluk trigliserid (TTG) düzeyi ve koroner arter hastalığı (KAH) arasındaki ilişkiyi araştırmayı amaçladık. Yöntemler: Bu prospektif kohort çalışmasına toplam 80 hasta dahil edildi ve TTG düzeyini ölçmek için ağızdan lipit yüklemesi yapıldı. Aç olarak ve lipitten zengin bir kahvaltı sonrası 2., 4., 6. ve 8. saatte tok olarak trigliserid düzeyi enzimatik yöntemle ölçüldü. Açlık trigliserid yüksekliği olan ve olmayan bireylerde lipit yüklemesinin trigliserid düzeyi üzerine etkisinin değerlendirilmesi için alt grup analizi uygulandı. Lipid yüklemesi sonrası trigliserid düzeyleri ve trigliserid düzeyindeki yüzde değişim oranları "tekrarlayan değerler için genel lineer model" analizi ile değerlen-dirildi. Örneklem büyüklüğü hesaplandı. Bulgular: Başlangıçtaki klinik, demografik ve biyokimyasal ölçümlerin sonuçları gruplar arasında benzerdi. Her iki grupta da zirve trigliserid seviyesi lipit yüklemesi sonrası 4. saatteydi. Lipit yüklemesi sonrası her iki grupta da trigliserid düzeyleri başlangıca göre anlamlı olarak arttı (p<0.001) ancak bu değişimler iki grup arasında farklı değildi (p=0.279). Alt grup analizlerinde; açlık trigliserid yüksekliği olan alt grupta, trigliserid düzeyi eğrisi altında kalan alanda KAH grubunda kontrol grubuna göre anlamlı yükseklik vardı (334±103 vs. 233±58 mg/dl, p=0.02). Sonuç: Bizim sonuçlarımız, açlık trigliserid düzeyi yüksek olan hastalarda TTG yüksekliğinin KAH ile ilişkili olabileceğini, ancak açlık trigliserid düzeyi yüksek olmayan hastalarda TTG düzeyi ile KAH arasında bir ilişki olmadığını göstermektedir. ABSTRACTObjective: We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD). Methods: A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2 nd , 4 th , 6 th and 8 th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed. Results: Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4 th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02). Conclusion: Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high...

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Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study

Cited by 108 publications

References 54 publications

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men

Apolipoprotein B-48 to Triglyceride Ratio Is a Novel and Useful Marker for Detection of Type III Hyperlipidemia after Antihyperlipidemic Intervention

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

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