Abnormal serum free thyroid hormone levels due to heparin administration

Laji, Ken; Rhidha, B; John, Robert A.; Lazarus, John; Davies, J. S.

doi:10.1093/qjmed/94.9.471

Cited by 30 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reference values are shown in Table 1. Free T4 measurements were not used because of possible interaction with heparin used in central venous catheters 22 …”

Section: Methodsmentioning

confidence: 99%

Changes in thyroid hormone state in children receiving chemotherapy

Santen¹,

Thonissen²,

Kraker

et al. 2005

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Reference values are shown in Table 1. Free T4 measurements were not used because of possible interaction with heparin used in central venous catheters 22 …”

Section: Methodsmentioning

confidence: 99%

Changes in thyroid hormone state in children receiving chemotherapy

Santen¹,

Thonissen²,

Kraker

et al. 2005

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Because the half-life of low molecular heparin (enoxaparin) is prolonged, the waning effect on thyroid function after 6-24 h is unlikely to be the explanation of our data [13,17].…”

Section: Discussionmentioning

confidence: 84%

“…The plethora of literature on thyroid hormones and heparin was mainly based on case reports and weird thyroid function test explanations in the reviews [2,17].…”

Section: Discussionmentioning

confidence: 99%

Thyroid function is not affected 6 or 24 hours after subcutaneous low molecular weight heparin

Mansour¹,

Kadim²

2017

View full text Add to dashboard Cite

Thyroid function is not affected 6 or 24 hours after subcutaneous low molecular weight heparinKey words: low molecular weight heparin, enoxaparin, thyroid function, thyroid hormone.Słowa kluczowe: heparyna drobnocząsteczkowa, enoksaparyna, funkcja tarczycy, hormon tarczycy. AbstractIntroduction: There has been widespread use of low molecular weight heparin (LMWH) in medical and surgical practice over the years. Aim of the research:To see the effect of LMWH on thyroid function. Material and methods: a cross-sectional study was made of patients with acute coronary syndrome (ACS) admitted to the Faiha Hospital Coronary Care Unit (CCU) for the period from December 2014 to June 2015. We enrolled 70 patients, with no apparent clinical history or examination finding suggestive of thyroid disease. On admission for all, enoxaparin (4000-6000 units) was given subcutaneously once daily with other usual drugs used for ACS. Thyroid function test was done at baseline and after 6 h in 60 patients and after 24 h in 10 patients. Results: At the end of the study, we excluded three patients (TSH > 10 (1 patient) or TSH < 0.2 (2 patients)). So the total number of enrolled patients was 67; 57 patients were from the 6-hour group and 10 from the 24-hour group. Comparison between serum levels of thyroid hormones (TSH, free T4, total T4, and total T3) measured at time of admission, 6 h later in 57 patients and 24 h in 10 patients, showed no statistical difference in the level after low molecular weight heparin (enoxaparin) except for lower total T4 after 6 h (9.2 ±1.8 vs. 8.8 ±1.8 μg/dl, p = 0.003). Conclusions: Single-dose low molecular weight heparin (enoxaparin) given subcutaneously had no effect on thyroid hormone levels 6 or 24 h later in patients with ACS. StreszczenieWprowadzenie: Heparyna drobnocząsteczkowa ma od lat szerokie zastosowanie w praktyce medycznej, m.in. w chirurgii. Cel pracy: Poznanie wpływu heparyny drobnocząsteczkowej na funkcję tarczycy. Materiał i metody: Przeprowadzono przekrojowe badanie chorych z ostrymi zespołami wieńcowymi (ACS) przyjętych na oddział intensywnej opieki kardiologicznej (CCU) szpitala Faiha w okresie od grudnia 2014 r. do czerwca 2015 r. W badaniu wzięło udział 70 chorych bez wyraźnej historii klinicznej i bez wyników badań wskazujących na chorobę tarczycy. Przy przyjęciu wszystkim podawano raz dziennie enoksaparynę (4000-6000 jednostek) podskórnie wraz z innymi standardowymi lekami na ACS. Wyjściowo oraz po 6 godzinach u 60 chorych i po 24 godzinach u 10 chorych przeprowadzono badanie funkcji tarczycy. Wyniki: Na koniec badania wyłączono 3 pacjentów (TSH > 10 (1 pacjent) lub TSH < 0,2 (2 pacjentów)). Łącznie do badania włączono 67 pacjentów, przy czym 57 pochodziło z grupy badanej po 6 godzinach, a 10 z grupy badanej po 24 godzinach. Porównanie stężeń hormonów tarczycy w surowicy (TSH, wolna T4, całkowita T4 oraz całkowita T3) zmierzonych przy przyjęciu, po upływie 6 godzin u 57 chorych oraz po upływie 24 godzin u 10 chorych nie wykazało statystycznie istotnych różnic po podaniu heparyny dr...

show abstract

“…Schwankungen der Jodidzufuhr ausgleichen kann. [33,40,43,46] die Bindung. Auch angeborene TBG-Varianten füh-ren zu einer verminderten Bindungskapazität [23].…”

Section: Transport 5 Plasmatransportunclassified

Resorption, Transport und Bioverfügbarkeit von Schilddrüsenhormonen

Dietrich¹,

Brisseau²,

Boehm³

2008

Dtsch med Wochenschr

View full text Add to dashboard Cite

The frequently prescribed classical thyroid hormones (iodothyronines) are critical dose drugs with a narrow therapeutic index. Nowadays the mechanisms of their absorption, which takes place predominantly in the jejunum and ileum, have only partly been elucidated. Bioavailability of iodothyronines whose kinetics is subject to enterohepatic circulation, is about 70 %. Several factors influence their absorption including nutrients, drugs and concomitant diseases. After being absorbed only a small fraction of thyroid hormones circulates freely in plasma, whereas the greater portion is bound to plasma proteins. This binding, too, may be influenced by numerous factors; alterations by certain diseases and physiological conditions may lead to ambiguities in differential diagnosis. Intracellular accumulation of iodothyronines is accomplished by at least ten different active and energy-dependent transporters with variable tissue distribution. Particularly in critical illness (non-thyroidal illness syndrome) alterations of protein binding and membrane transport are common. In therapy of hypothyroid patients different brand-name products lack bioequivalence and thus requiring subsequent monitoring of thyroid status after treatment has been changed among different brand-name versions.

show abstract

Abnormal serum free thyroid hormone levels due to heparin administration

Cited by 30 publications

References 6 publications

Changes in thyroid hormone state in children receiving chemotherapy

Changes in thyroid hormone state in children receiving chemotherapy

Thyroid function is not affected 6 or 24 hours after subcutaneous low molecular weight heparin

Resorption, Transport und Bioverfügbarkeit von Schilddrüsenhormonen

Contact Info

Product

Resources

About