Abnormal Spontaneous Brain Activity in Early Parkinson’s Disease With Mild Cognitive Impairment: A Resting-State fMRI Study

Wang, Zhijiang; Jia, Xiuqin; Chen, Huimin; Feng, Tao; Wang, Huali

doi:10.3389/fphys.2018.01093

Cited by 49 publications

(39 citation statements)

References 52 publications

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“…In addition, studies have found that Parkinson's disease (PD), Huntington's disease, schizophrenia, major depressive disorder, type 2 diabetes mellitus (T2DM), chronic obstructive pulmonary disease (COPD), lung cancer following chemotherapy, hepatic encephalopathy, kidney deficiency syndrome, and other diseases can also cause CI (70)(71)(72)(73)(74)(75)(76)(77)(78)(79), but the relationships between these diseases and cognitive function and the pathogenesis of CI are still unknown, necessitating further in-depth studies. rs-fMRI will play an important role in the exploration of these unknown areas.…”

Section: Application Of Rs-fmri In Mild Traumatic Brain Injury (Mtbi)mentioning

confidence: 99%

The Application of rs-fMRI in Vascular Cognitive Impairment

et al. 2020

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The incidence of vascular cognitive impairment (VCI) has been increasing for years and has become a major disabling factor in middle-aged and elderly populations. The pathogenesis of VCI is unclear, and there are no standard diagnostic criteria. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to detect spontaneous brain functional activity in a resting state, which facilitates in-depth investigation of the pathogenesis of VCI and provides an objective reference for early diagnosis, differential diagnosis, and prognostic evaluation. This article mainly reviews the principle and analysis of rs-fMRI data, as well as the progress of its application for VCI diagnosis.

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Section: Application Of Rs-fmri In Mild Traumatic Brain Injury (Mtbi)mentioning

confidence: 99%

The Application of rs-fMRI in Vascular Cognitive Impairment

et al. 2020

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“…Relative to routine ALFF (generally in the range of 0.01–0.1 Hz), it is more rational to depict brain activity by measuring the amplitude of spontaneous fluctuations at specific frequencies, and also in broader frequency bands [12]. Several studies found the frequency-dependent ALFF alterations in neuropsychiatric diseases, such as epilepsy, Parkinson’s disease, and insomnia [13-15]. These findings suggest that we should carefully consider the frequency-dependent effect on intrinsic local neuronal activity.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression

et al. 2019

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Background/Aims: Although abnormalities of amplitude of low-frequency fluctuations (ALFF) and hormone levels of hypothalamus-pituitary-thyroid axis have been reported in patients with bipolar disorder (BD), the association between abnormal ALFF and serum thyroid hormone levels remains unknown. Method: A total of 90 patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging, and then routine band (0.01–0.1 Hz), slow-5 band (0.01–0.027 Hz), and slow-4 band (0.027–0.073 Hz) ALFF analysis were performed. Additionally, serum thyroid hormone levels including free tri-iodothyronine (FT3), total tri-iodothyronine (TT3), free thyroxin (FT4), total thyroxin (TT4), and thyroid-stimulating hormone (TSH) were detected. The correlation between abnormal serum thyroid hormone levels and ALFF values in patients with BD II depression was calculated. Results: Compared with the HCs, patients with BD II depression showed decreased ALFF in bilateral precuneus (PCu)/posterior cingulate cortex (PCC) in routine and slow-4 frequency bands, decreased ALFF in the right PCu, and increased ALFF in the right middle occipital gyrus (MOG) in the slow-5 frequency band. Additionally, patients with BD II depression showed lower TSH level than HCs, and TSH level was positively correlated with ALFF values in the bilateral PCu/PCC in the routine frequency band. Conclusions: These findings suggest that patients with BD II depression display intrinsic activity abnormalities, mainly in the PCu/PCC and MOG, which are associated with specific frequency bands. Moreover, altered intrinsic activity in the PCu/PCC may be related to TSH levels in bipolar II depression.

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“…Spontaneous brain activity de cit in the left inferior frontal gyrus was restored in the PD patient after treatment [28]. Specially, the non-treatment PD-MCI group also exhibited increased ALFF in the inferior frontal gyrus [29]. And the increased activity in the inferior frontal gyrus was also found in the PD_MCI patients during performing a planning set-shifts task [30].…”

Section: Discussionmentioning

confidence: 85%

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

Ji¹,

Zhao²,

Cui³

et al. 2020

Preprint

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Background: Parkinson's disease (PD) is often associated with cognitive impairment. However, the neural mechanism of cognitive impairment is not clear. The present study investigated the functional and anatomic changes in PD patients with mild cognitive impairment (MCI) and their correlations with cognitive functions by the application of combined functional and structural analysis. Methods: T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI data were acquired from 23 PD patients with MCI (PD-MCI), 23 PD patients with normal cognitive function (PD-NCI), and 23 matched healthy controls (HC). The structural imaging data was analyzed by voxel-based morphometry (VBM) and surfaced-based morphometry (SBM) methods to assess the changes of gray matter density and cortical thickness, respectively. And the amplitude of low-frequency fluctuations (ALFF) analysis using resting-state functional imaging data to measure the spontaneous changes of brain activity. Their Correlations with neuropsychological assessments (e.g., Montreal cognitive assessment, MOCA; Mini-mental state examination, MMSE) were also examined. Results: Compared to the HC group, the PD-MCI patient group showed both decreased ALFF in the occipital regions (i.e., left middle occipital gyrus) and parietal regions (i.e., left precuneus) and increased ALFF in the right inferior frontal gyrus and bilateral hippocampus. Also, the PD-MCI patient group showed reduced gray matter density in the right inferior frontal gyrus and middle frontal gyrus. Cortical thinning in the left middle temporal gyrus and right superior temporal gyrus was found in the PD_MCI patient group relative to the control group. Furthermore, ALFF of the right hippocampus and gray matter density of right frontal gyrus was correlated with cognitive impairment (e.g., MOCA ), respectively. Cortical thickness of right superior temporal gyrus was also associated with cognitive deficit (e.g., MMSE ). Conclusion: MCI in PD is associated with widespread brain functional and structural alternations. The combination of functional and structural abnormalities may be related to subtle cognitive impairment in PD.

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Abnormal Spontaneous Brain Activity in Early Parkinson’s Disease With Mild Cognitive Impairment: A Resting-State fMRI Study

Cited by 49 publications

References 52 publications

The Application of rs-fMRI in Vascular Cognitive Impairment

The Application of rs-fMRI in Vascular Cognitive Impairment

Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

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