Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy

Sun, Huiyuan; Hu, Jian-Bin; Chen, Jing; Wang, Xue-Yang; Wang, Xiaoli; Pan, PingLei; Liu, Chunfeng

doi:10.3389/fnins.2020.00830

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…Functional data was preprocessed using the rs-fMRI data processing assistant (DPABI_V4.3, Beijing, China) 1 base on the MATLAB 2013b 2 platform. The preprocessing steps are consistent with previous literature (Xue et al, 2019;Li K. et al, 2020;Sun et al, 2020;Wang et al, 2020). The specific steps are described below.…”

Section: Data Preprocessingmentioning

confidence: 84%

Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson’s Disease With Subthalamic Microlesion

et al. 2021

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BackgroundTransient improvement in motor symptoms are immediately observed in patients with Parkinson’s disease (PD) after an electrode has been implanted into the subthalamic nucleus (STN) for deep brain stimulation (DBS). This phenomenon is known as the microlesion effect (MLE). However, the underlying mechanisms of MLE is poorly understood.PurposeWe utilized resting state functional MRI (rs-fMRI) to evaluate changes in spontaneous brain activity and networks in PD patients during the microlesion period after DBS.MethodOverall, 37 PD patients and 13 gender- and age-matched healthy controls (HCs) were recruited for this study. Rs-MRI information was collected from PD patients three days before DBS and one day after DBS, whereas the HCs group was scanned once. We utilized the amplitude of low-frequency fluctuation (ALFF) method in order to analyze differences in spontaneous whole-brain activity among all subjects. Furthermore, functional connectivity (FC) was applied to investigate connections between other brain regions and brain areas with significantly different ALFF before and after surgery in PD patients.ResultRelative to the PD-Pre-DBS group, the PD-Post-DBS group had higher ALFF in the right putamen, right inferior frontal gyrus, right precentral gyrus and lower ALFF in right angular gyrus, right precuneus, right posterior cingulate gyrus (PCC), left insula, left middle temporal gyrus (MTG), bilateral middle frontal gyrus and bilateral superior frontal gyrus (dorsolateral). Functional connectivity analysis revealed that these brain regions with significantly different ALFF scores demonstrated abnormal FC, largely in the temporal, prefrontal cortices and default mode network (DMN).ConclusionThe subthalamic microlesion caused by DBS in PD was found to not only improve the activity of the basal ganglia-thalamocortical circuit, but also reduce the activity of the DMN and executive control network (ECN) related brain regions. Results from this study provide new insights into the mechanism of MLE.

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Section: Data Preprocessingmentioning

confidence: 84%

Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson’s Disease With Subthalamic Microlesion

et al. 2021

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“…In this regard, increased connectivity between the ventral tegmental area and the ACC was reported in depressive as compared to non-depressive PD patients [ 153 ], in addition to network dysfunction of the PCC in depressive PD patients [ 154 ]. Furthermore, apathy was also associated with reduced neuronal activity [ 155 ], microstructural alterations [ 156 ] and an increase in amyloid depositions in the ACC [ 157 ], whereas anxiety was related to thinning of the cingulate cortex [ 44 ]. In turn, functional connectivity between the anterior cingulate and the temporo-parietal junction was positively correlated with a higher quality of life in PD [ 158 ].…”

Section: Regions Of the Limbic Systemmentioning

confidence: 99%

“…There was an inverse correlation between DAT availability and severity of depression [ 252 ]. Apathy in PD was associated with reduced amplitude of low-frequency fluctuations as compared to PD controls indicating lower neuronal activity in this brain region [ 155 ]. Atrophy of the nucleus accumbens was also reported in patients with apathy [ 163 ].…”

Section: Regions Of the Limbic Systemmentioning

confidence: 99%

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

et al. 2022

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The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson’s disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

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“…In addition, due to the different populations selected in the two studies, it was impossible to compare the two studies, and the two studies were single-center studies, which was not enough to represent the whole group, and more studies are needed to verify in the further. The ALFF reflected the spontaneous neural activity of local brain regions by detecting the intensity of spontaneous activity of neurons in a specific frequency range ( Gong et al, 2020 ; Sun et al, 2020 ). The seed-based FC calculated the time series correlation between the average time series of the region of interest (ROI) and other voxels in the whole brain to reflect the integration function of the brain networks ( Baggio et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

Lin,

Liu,

Liu

et al. 2023

Front. Neurosci.

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ObjectiveBenign paroxysmal positional vertigo (BPPV) is a common clinical vertigo disease, and the most effective treatment for this disease is canal repositioning procedures (CRP). Most patients return to normal after a single treatment. However, some patients still experience residual dizziness (RD) after treatment, and this disease’s pathogenesis is currently unclear. The purpose of this study is to explore whether there are abnormal brain functional activities in patients with RD by using resting-state functional magnetic resonance imaging (rs-fMRI) and to provide imaging evidence for the study of the pathogenesis of RD.Materials and methodsThe BPPV patients in the Second Affiliated Hospital of Xuzhou Medical University had been included from December 2021 to November 2022. All patients had been received the collection of demographic and clinical characteristics (age, gender, involved semicircular canal, affected side, CRP times, BPPV course, duration of RD symptoms, and whether they had hypertension, diabetes, coronary heart disease.), scale assessment, including Dizziness Handicap Inventory (DHI), Hamilton Anxiety Inventory (HAMA), Hamilton Depression Inventory (HAMD), rs-fMRI data collection, CRP treatment, and then a one-month follow-up. According to the follow-up results, 18 patients with RD were included. At the same time, we selected 19 healthy individuals from our hospital’s physical examination center who matched their age, gender as health controls (HC). First, the amplitude of low-frequency fluctuations (ALFF) analysis method was used to compare the local functional activities of the two groups of subjects. Then, the brain regions with different ALFF results were extracted as seed points. Functional connectivity (FC) analysis method based on seed points was used to explore the whole brain FC of patients with RD. Finally, a correlation analysis between clinical features and rs-fMRI data was performed.ResultsCompared to the HC, patients with RD showed lower ALFF value in the right precuneus and higher ALFF value in the right superior temporal gyrus (STG). When using the right STG as a seed point, it was found that the FC between the right STG, the right supramarginal gyrus (SMG), and the left precuneus was decreased in RD patients. However, no significant abnormalities in the FC were observed when using the right precuneus as a seed point.ConclusionIn patients with RD, the local functional activity of the right precuneus is weakened, and the local functional activity of the right STG is enhanced. Furthermore, the FC between the right STG, the right SMG, and the left precuneus is weakened. These changes may explain the symptoms of dizziness, floating sensation, walking instability, neck tightness, and other symptoms in patients with RD to a certain extent.

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Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy

Cited by 8 publications

References 57 publications

Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson’s Disease With Subthalamic Microlesion

Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson’s Disease With Subthalamic Microlesion

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

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