Abnormal sulcation as an early sign for migration disorders

Malinger, G.; Lev, Dorit; Lerman‐Sagie, T.

doi:10.1002/uog.1795

Cited by 32 publications

(35 citation statements)

References 7 publications

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“…In utero, it is usually diagnosed following the development of microcephaly and/or abnormal sulcation and gyration, frequently associated with commissural dysgenesis [16,35,36] . Congenital CMV infection during the late first or early second tri- …”

Section: Malformations Of Cortical Developmentmentioning

confidence: 99%

Imaging of Fetal Cytomegalovirus Infection

Malinger¹,

Lev²,

Lerman‐Sagie³

2010

Fetal Diagn Ther

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Fetuses with congenital cytomegalovirus infection may remain asymptomatic or present with a wide range of brain pathologies. These findings are not always obvious but may on some occasions be demonstrated by ultrasound and MRI, they include ventriculomegaly, microcephaly, increased periventricular echogenicity, calcifications, periventricular pseudocysts, intraventricular synechia, malformations of cortical development, cerebellar lesions and T2 abnormal temporal signals. The purpose of this mini-review is to describe US and MRI findings characteristic of congenital cytomegalovirus infection, with particular emphasis on their time of appearance, frequency and specificity.

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Section: Malformations Of Cortical Developmentmentioning

confidence: 99%

Imaging of Fetal Cytomegalovirus Infection

Malinger¹,

Lev²,

Lerman‐Sagie³

2010

Fetal Diagn Ther

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“…Abnormal sulcus development could be an early warning sign of an underlying fetal neurodevelopment migration disorder,[22] which may present clinically with cognitive deficits, epilepsy, and/or motor deficits. [15] Abnormal SF development seems to be the main marker of abnormal gyration.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Characteristics of Cortical Sulcus Development in the Human Fetus between 18 and 41 Weeks of Gestation

Chen¹,

Li²,

Luo

et al. 2017

Chinese Medical Journal

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Background:Fetal brain development is a complicated process that continues throughout pregnancy. Fetal sulcus development has typical morphological features. Assessment of fetal sulcus development to understand the cortical maturation and development by prenatal ultrasound has become widespread. This study aimed to explore a reliable method to assess cortical sulcus and to describe the normal sonographic features of cortical sulcus development in the human fetus between 18 and 41 weeks of gestation.Methods:A cross-sectional study was designed to examine the fetal cortical sulcus development at 18–41 weeks of gestation. Ultrasound was used to examine the insula, sylvian fissure (SF), parieto-occipital fissure (POF), and calcarine fissure (CF). Bland-Altman plots were used for assessing the concordance, and the intraclass correlation coefficient was used for assessing the reliability.Results:SF images were successfully obtained in 100% of participants at 22 weeks of gestation, while the POF images and CF images could be obtained in 100% at 23 weeks of gestation and 24 weeks of gestation, respectively. The SF width, temporal lobe depth, POF depth, and the CF depth increased with the developed gestation. The width of uncovered insula and the POF angle decreased with the developed gestation. By 23 weeks of gestation, the insula was beginning to be covered. Moreover, it completed at 35 weeks of gestation. The intra- and inter-observer agreements showed consistent reproducibility.Conclusions:This study defined standard views of the fetal sulcus as well as the normal reference ranges of these sulcus measurements between 18 and 41 weeks of gestation. Such ultrasonographic measurements could be used to identify fetuses at risk of fetal neurological structural disorders.

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“…In two of our cases, abnormalities of the intermediate zone were the earliest indication of CMV infection, predating the development of microcephaly, ventriculomegaly and intracranial calcification (Figure ). It is important to note that a congenital or acquired process that interferes with neuronal migration and development of a normal cerebral lamination pattern can be predicted to disrupt normal gyral and sulcal development.…”

Section: Discussionmentioning

confidence: 99%