Abnormal uterine bleeding in puberty: diagnosis and treatment

Adamyan, L. V.; Sibirskaya, E. V.; Koltunova, I. E.; Loginova, O. N.; Tarbaya, N. O.; Osipova, G. T.; Pakhomova, P. I.

doi:10.17116/repro201622689-97

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Етіологія АМК ПП пов'язана з віковою нестійкістю регуляторних механізмів ендокринної системи та її високою чутливістю до несприятливих впливів у період статевого дозрівання [5]. Фактори, які можуть спричинити ювенільні кровотечі: генітальні та екстрагенітальні захворювання матері, патологічний перебіг антенатального періоду, інфекційні та хронічні соматичні захворювання дівчинки, стрес, ендокринопатії [1,5,6]. Несприятливий перебіг антенатального періоду може призвести до внутрішньоутробно розвиненої недостатності як самих гонад, так і неспроможності центральних регулювальних ланцюгів репродуктивної системи [7].…”

Section: аномальные маточные кровотечения пубертатного периода: к воп...unclassified

“…); • супутні симптоми -виділення з піхви та/або запах, тазовий біль, підвищений артеріальний тиск [8]. Також слід з'ясувати сімейний анамнез: наявність спадкових порушень згортання крові, гормонозалежних пухлин, тромбоемболічних захворювань або серцево-судинних порушень, що має важливе значення під час вибору тактики лікування АМК ПП [2,6,9].…”

Section: аномальные маточные кровотечения пубертатного периода: к воп...unclassified

“…Найчастіше у 22 (78,6%) дівчат із мутацією С677Т гена MTHFR і у 28 (87,5%) дівчат без даної мутації АМК ПП маніфестувало у віці 12-14 років, що збігається з віком появи маткової кровотечі у дівчат за даними літератури [6,11,16].…”

Section: езультати дослідження та їх обговоренняunclassified

“…У 22 (78,6%) дівчат з АМК ПП та наявністю мутації С677Т гена MTHFR виявлено потовщення ендометрія (М-ехо=16,2±0,6 мм): у дівчат з АМК ПП переважала поліпозна форма гіперплазії ендометрія (50,0%), вогнищева гіперплазія ендометрія виявлена у 31,3% випадків, дифузна форма -у 18,7%. Отримані дані достовірно не відрізнялися від частоти гіперплазії ендометрія у дівчат з АМК ПП без даної мутації і співпадали з даними деяких вітчизняних та зарубіжних авторів про частоту гіперплазії ендометрія у дівчат з АМК ПП [6,14,24].…”

Section: езультати дослідження та їх обговоренняunclassified

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Abnormal uterine bleeding during puberty: to the pathogenesis and diagnosis

Kovalishin

2022

RHW

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The objective: to study the genetic aspects of the pathogenesis of abnormal uterine bleeding during puberty (AUB PP) and to evaluate the effectiveness of diagnostic measures taking into account the presence or absence of mutations in the MTHFR C677T gene.Materials and methods. Sixty girls with a history of AUB PP were included in the main group and 30 healthy girls without AUB consisted the control group. The main group is divided into three subgroups: the 1st subgroup (n=20) – the girls with AUB PP, born from the mothers with physiological pregnancy; the 2d subgroup 2 (n=20) – the girls with AUB PP, born form the mothers whose pregnancy was complicated by preeclampsia; the 3d subgroup (n=20) – the girls with AUB PP, born from the mothers with a history of miscarriage.All persons were examined with the study of reproductive and menstrual functions, the assessment of hormonal status, family and hereditary anamnesis, ultrasound examination of the pelvic organs in the dynamics of the menstrual cycle. Depending on the duration of bleeding and the severity of compensatory disorders, the severity of anemia the mutations in the MTHFR C677T gene and homocysteine concentration were determined in girls and their mothers in the blood, the assessment of menstrual blood clotting and morphological status of the endometrium were performed.Results. The mothers of girls with AUB PP had pregnancy complications significantly more often (reccurent miscarriages – 28.0 %, preeclampsia - 25.8 %) than mothers of healthy girls (14.0 % and 12.2 %, respectively), in 55,0 % of cases a mutation in the MTHFR C677T gene was detected, which is absent in mothers of healthy girls. The majority of girls with AUB PP born from the mothers with a history of miscarriage (70.0 %) or preeclampsia (60.0 %) was 7 and 6 times more likely to have mutations in the MTHFR C677T gene, respectively, than girls with AUB PP who were born from the mothers with physiological pregnancies without complications (10.0 %). Mutation of the MTHFR C677T gene was found in 3.3 % of healthy girls.Serum homocysteine levels in girls and their mothers who had the MTHFR C677T gene mutation were 6.0±1.2 and 8.0±1.0 μmol/L, respectively, and did not differ significantly from those in girls and mothers without the mutation. The clinical picture and state of the hemostasis system in girls with AUB PP and the presence of mutations in the MTHFR C677T gene also did not differ significantly from the clinical picture of girls with AUB PP without this mutation and healthy girls. But in the menstrual blood of girls with AUB PP and mutations in the MTHFR C677T gene, hyperfibrinolysis was significantly more pronounced than in the menstrual blood of healthy girls and girls with AUB PP without gene mutations.Conclusions. The analysis of the presence of mutations in the MTHFR C677T gene in girls with AUB PP demonstrates that mutation in this gene is 6 times more often in patients who were born from the pregnancies complicated by preeclampsia, and 7 times more often in girls with AUB PP who were born from the mothers with pregnancy loss in the anamnesis, in comparison with those who were born from physiologically normal pregnancy.

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Section: аномальные маточные кровотечения пубертатного периода: к воп...unclassified

Section: езультати дослідження та їх обговоренняunclassified

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Abnormal uterine bleeding during puberty: to the pathogenesis and diagnosis

Kovalishin

2022

RHW

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Eating Disorders in Adolescent Girls. Gynecologist’s Point of View

Sibirskaya,

Karachentsova,

Naumova

et al. 2024

Pediatr. farmakol.

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This review presents an analysis of the literature data for the last 10 years (2012–2022) investigating the effect of eating disorders on the health of adolescent girl, its diagnosis, and possible tactics of gynecologist. The most common predictor of restoring menstrual function in girls with this pathology is body mass index change, however normalization of weight does not lead to remission in all cases. Thus, estimation of fat percentage, insulin-like growth factor, and leptin is more effective. We suggest directing further research on the study of more effective methods of reproductive disorders correction and the development of multidisciplinary clinical guidelines for the effective diagnosis and management of eating disorders and any gynecological complications.

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Abnormal Uterine Bleeding in Adolescence Burdened with Severe Anemia: Clinical Case

Adamyan,

Sibirskaya,

Karachentsova

et al. 2023

Vopr. sovr. pediatr.

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Background. Abnormal uterine bleeding (AUB) in adolescence is one of the urgent problems of medicine nowadays. It is on the 2nd place among all the reasons for hospitalization in gynecological departments, and its incidence among girls during puberty is 50%. Clinical case description. This is the clinical case of 15-year-old girl admitted to the gynecology department with complaints on long-lasting bloody vaginal discharge, fatigue, dizziness. The diagnosis of «abnormal uterine bleeding in adolescence» burdened with iron deficiency anemia (IDA) was established according to laboratory and instrumental examinations. The patient underwent RBC-transfusion with specific buffy coat and was administered with hormonal hemostatic and anti-anemic therapy. Conclusion. We can conclude (with reference to this observation and the reviewed literature) not only that IDA is one of the most common complications of AUB in adolescence, but also what management should be used in such clinical cases.

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Abnormal uterine bleeding in puberty: diagnosis and treatment

Cited by 6 publications

References 9 publications

Abnormal uterine bleeding during puberty: to the pathogenesis and diagnosis

Abnormal uterine bleeding during puberty: to the pathogenesis and diagnosis

Eating Disorders in Adolescent Girls. Gynecologist’s Point of View

Abnormal Uterine Bleeding in Adolescence Burdened with Severe Anemia: Clinical Case

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