Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-center observational study

Zhu, Bin; Shen, Jianqin; Jiang, Ruiwei; Jin, Lina; Zhan, Gaofeng; Liu, Jinfeng; Sha, Qiuying; Xu, Rongpeng; Miao, Lei; Yang, Chun

doi:10.1007/s00213-020-05569-x

“…Recently, increasing evidence has shown that gut microbiome disorders are strongly linked to the onset and progression of nervous system diseases, the underlying mechanism of which may be related to the ‘microbe-gut-brain’ axis [ 6 ]. This association has been reported in various conditions, including Alzheimer’s disease [ 7 ], hypertension [ 8 ], ESRD [ 9 ], and in those undergoing haemodialysis [ 10 ]. However, the relationship between cognitive impairment and the faecal microbiome in patients undergoing PD remains unclear.…”

Section: Introductionmentioning

confidence: 78%

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Wang,

Wu,

Zhang

et al. 2023

BMC Nephrol

6

0

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Background Growing evidence has demonstrated that patients undergoing peritoneal dialysis (PD) are more likely to experience cognitive impairment than patients with non-dialysis end-stage renal disease (ESRD); however, the underlying mechanisms remain unclear. This study aimed to identify the role and predictive significance of gut microbiome alterations in PD-associated cognitive impairment. Methods A total of 29 non-dialysis ESRD patients and 28 PD patients were enrolled in this study and divided into subgroups according to the Montreal Cognitive Assessment (MoCA). Faecal samples were analyzed using 16 S rRNA. Mini-Mental State Examination (MMSE) and MoCA scores were used to assess the degree of cognitive impairment in patients. Results The 16 S rRNA analysis demonstrated differences in gut microbiome abundance and structure between PD and non-dialysis ESRD patients and between PD patients with cognitive impairment (PCI) and PD patients with normal cognition (PNCI). At family and genus levels, Prevotellaceae exhibited the greatest structure difference, while Lactobacillus exhibited the greatest abundance difference between PCI and PNCI. Altered microbiota abundance significantly correlated with cognitive function and serum indicators in PD. In addition, different modules related to fatty acid, lipid, pantothenate, and coenzyme A biosynthesis, and tyrosine and tryptophan metabolism were inferred from 16 S rRNA data between PCI and PNCI. Both groups could be distinguished using models based on the abundance of Lactobacillaceae (Area under curve [AUC] = 0.83), Actinomycetaceae (AUC = 0.798), and Prevotellaceae (AUC = 0.778) families and Lactobacillus (AUC = 0.848) and Actinomyces (AUC = 0.798) genera. Conclusion Gut microbiome evaluation could aid early cognitive impairment diagnosis in patients undergoing PD.

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“…Similarly, patients on hemodialysis with mild cognitive decline were also found to have significantly less Lachnospira spp. compared to patients with normal cognitive function and healthy controls (Zhu et al, 2020). Despite these findings, a study involving children of similar age groups reported an unclassified lineage within the Lachnospiraceae family was associated with behavioral issues (Loughman et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, patients on hemodialysis with mild cognitive decline were also found to have significantly less Lachnospira spp. compared to patients with normal cognitive function and healthy controls (Zhu et al, 2020).…”

Section: Longitudinal Associations Between Microbiota Composition And...mentioning

confidence: 99%

Cross‐sectional and longitudinal associations between gut microbiota composition and cognition in the second year of life: Findings from the Child Health and Resident Microbes study

Matsuyama

¹

,

Murtaza

²

,

Morrison

³

et al. 2022

American J of Med Genetics Pt B

1

0

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The relationship between the gut microbiota and brain function are receiving increasing research attention. Studies investigating gut microbiota and early childhood neurocognition are limited, particularly in longitudinal measurements. We examined cross‐sectional relationships between gut microbiota of a cohort of otherwise healthy children using 16S rRNA sequencing and their cognitive development measured with Bayley's Scales of Infant Development III at 24 months of age (n = 43), and longitudinal relationships between gut microbiota composition at 12 months (n = 41) of age and neurodevelopment at 24 months of age. Associations between gut microbiota characteristics and cognitive development were observed both cross‐sectionally and longitudinally, notably with butyrate producing bacteria among some children. Bacterial diversity varied between cross‐sectional and longitudinal observations, where the gut microbiota community of children with lower cognitive scores had a trend toward higher alpha diversity, whereas, in the longitudinal observation, a trend toward reduced alpha diversity was observed. This study is limited by a small sample size and its exploratory nature. Yet, the study contributes to knowledge in the gut microbiota characteristics and early life neurodevelopment, a field of study which is underexplored, presenting opportunities for future larger specific studies.

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“…Analysis for α -diversity, such as Shannon index, Simpson index, Chao 1 index, and observed species, was detailed in previous research [ 31 ]. Linear discriminant analysis (LDA) of effect size (LEfSe) was performed according to Zhu et al [ 32 ]. Nonmetric multidimensional scaling (NMDS) based on Bray-Curtis distance, analysis of similarities (ANOSIM), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was described in the research implemented by Lei et al [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Zengye Decoction Attenuated Severe Acute Pancreatitis Complicated with Acute Kidney Injury by Modulating the Gut Microbiome and Serum Amino Acid Metabolome

Dai

¹

,

Hu

²

,

Yao

³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect and underlying mechanism of Zengye decoction (ZYD), a traditional formula from China, on the severe acute pancreatitis (SAP) rat model with acute kidney injury (AKI). Methods. The SAP-AKI model was induced by 3.5% sodium taurocholate. Rats were treated with normal saline or ZYD twice and sacrificed at 36 h after modeling. Amylase, lipase, creatinine, blood urea nitrogen, kidney injury molecule 1(KIM-1), and multiple organs’ pathological examinations were used to assess the protective effect of ZYD. Gut microbiome detected by 16S rRNA sequencing analysis and serum amino acid metabolome analyzed by liquid chromatography-mass spectrometry explained the underlying mechanism. The Spearman correlation analysis presented the relationship between microflora and metabolites. Results. ZYD significantly decreased KIM-1( P < 0.05 ) and the pathological score of the pancreas ( P < 0.05 ), colon ( P < 0.05 ), and kidney ( P < 0.05 ). Meanwhile, ZYD shifted the overall gut microbial structure (β-diversity, ANOSIM R = 0.14, P = 0.025 ) and altered the microbial compositions. Notably, ZYD reduced the potentially pathogenic bacteria—Bacteroidetes, Clostridiales vadin BB60 group, and uncultured_Clostridiales_bacterium, but promoted the short-chain fatty acid (SCFA) producers—Erysipelotrichaceae, Bifidobacterium, Lactobacillus, and Moryella (all P < 0.05 ). Moreover, principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and hierarchical clustering analysis (HCA) presented a remarkable change in amino acid metabolome after SAP-AKI induction and an apparent regulation by ZYD treatment (R2Y 0.878, P = 0.01 ; Q2 0.531, P = 0.01 ). Spearman’s correlation analysis suggested that gut bacteria likely influenced serum metabolites levels (absolute r > 0.4 and FDR P < 0.02 ). Conclusions. ZYD attenuated SAP-AKI by modulating the gut microbiome and serum amino acid metabolome, which may be a promising adjuvant treatment.

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Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-center observational study

Cited by 11 publications

References 38 publications

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Cross‐sectional and longitudinal associations between gut microbiota composition and cognition in the second year of life: Findings from the Child Health and Resident Microbes study

Zengye Decoction Attenuated Severe Acute Pancreatitis Complicated with Acute Kidney Injury by Modulating the Gut Microbiome and Serum Amino Acid Metabolome

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