Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia

Brunet, Éric; Sarfati, Yves; Hardy-Baylé, Marie-Christine; Decety, Jean

doi:10.1016/s0028-3932(03)00119-2

Cited by 178 publications

(122 citation statements)

References 39 publications

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“…Clinical assessment included: The Premorbid Adjustment Scale (PAS; Cannon-Spoor, Potkin, & Wyatt, 1982), the Positive and Negative Symptom Scale (PANSS; , and the Calgary Depression Scale (Addington, Addington, & Schissel, 1990). The Global Assessment of Functioning (GAF; APA, 1994) was also used to assess patient's global psychological, social, and occupational functioning.…”

Section: Assessmentmentioning

confidence: 99%

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

Pousa¹,

Duñó²,

Navarro³

et al. 2008

Schizophrenia Research

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Section: Assessmentmentioning

confidence: 99%

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

Pousa¹,

Duñó²,

Navarro³

et al. 2008

Schizophrenia Research

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“…especially in the left inferior frontal gyrus (Russell, et al, 2000) and right posterior orbital cortex (Brunet et al, 2003) during the performance of the Eyes-test has been shown. Regarding the sense of agency, an abnormal hyper-activation of the IPL, the brain area critical for distinguishing internally produced actions from those generated by others (Decety et al, 2002, Farrer et al, 2004, Decety and Lamm, 2006, Schnell et al, 2007 has been found in schizophrenia, especially in patients with firstrank symptoms (Spence et al, 1997, Farrer, et al, 2004.…”

mentioning

confidence: 90%

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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The sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency and mentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self-or other-generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the mind in the eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated. Both sense of agency and mentalizing were impaired in schizophrenia patients compared to healthy controls. However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group. The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia, suggesting that the multifaceted construct of social cognition consists of independent subdomains in healthy and psychiatrically ill individuals. AbstractThe sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency andmentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self or other generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the Mind in the Eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated.Both sense of agency and mentalizing were impaired in schizophrenics compared to healthy controls.However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group.The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia,suggesting that the multifaceted construct of social cognition consists of independ...

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“…Therefore, methods of measuring regional CBF, such as H 2 O 15 positron emission tomography (PET), dynamic contrast enhanced (DCE) MRI and arterial spin labeling (ASL) MRI are important tools in studying brain pathology Brunet et al, 2003;Dieterich et al, 2005;Golay et al, 2004) as well as normal brain function (Kim and Ugurbil, 1997;Wang et al, 2003a). Measurement of CBF with ASL offers several practical and scientific advantages over PET and DCE methods .…”

Section: Introductionmentioning

confidence: 99%

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

et al. 2008

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Variance estimates can be used in conjunction with scientifically meaningful effect sizes to design experiments with type II error control. Here we present estimates of intra-and inter-subject variances for region of interest (ROI) from resting cerebral blood flow (CBF) maps obtained using whole brain, spin echo echoplanar (SE-EPI) continuous arterial spin labeling (CASL) imaging on 52 elderly subjects (age = 70.5 ± 7.9 years, 29 males). There was substantial intrasubject systematic variability in CBF of gray matter ROIs corresponding to a range of standard deviations = [39 -168] (mL/ (100g·min)). This variability was mainly due to two factors: 1) an expected inverse relationship between ROI volume and intrasubject variance, and 2) an increased effective post-labeling delay for more superior slices acquired later in the sequence. For example, intrasubject variance in Brodmann Area 4 (BA 4) was ∼ 8 times larger than in hippocampus, despite their similar gray matter volumes. Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent samples t-test and paired t-test. The theoretical effects of pulse sequence and field strength on general applicability of these results are discussed.

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Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia

Cited by 178 publications

References 39 publications

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

Exploratory Study of the Association Between Insight and Theory of Mind (Tom) in Stable Schizophrenia Patients

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

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