Abnormalities of the type I interferon signaling pathway in lupus autoimmunity

Gallucci, Stefania; Meka, Sowmya; Gamero, Ana M.

doi:10.1016/j.cyto.2021.155633

Cited by 47 publications

(23 citation statements)

References 183 publications

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“…Also, common polymorphisms in or near TLR7, which are related to the synthesis of interferons, seems to be involved with the development of the disease. In fact, recent evidence confirmed human SLE caused by a TLR7 gain-of-function variant ( 9 – 11 ).…”

Section: Sle Generalitiesmentioning

confidence: 88%

Placental damage in pregnancies with systemic lupus erythematosus: A narrative review

Gutierrez

Figueras²,

Morales-Prieto³

et al. 2022

Front. Immunol.

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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown cause, which mainly affects women of childbearing age, especially between 15 and 55 years of age. During pregnancy, SLE is associated with a high risk of perinatal morbidity and mortality. Among the most frequent complications are spontaneous abortion, fetal death, prematurity, intrauterine Fetal growth restriction (FGR), and preeclampsia (PE). The pathophysiology underlying obstetric mortality and morbidity in SLE is still under investigation, but several studies in recent years have suggested that placental dysfunction may play a crucial role. Understanding this association will contribute to developing therapeutic options and improving patient management thus reducing the occurrence of adverse pregnancy outcomes in this group of women. In this review, we will focus on the relationship between SLE and placental insufficiency leading to adverse pregnancy outcomes.

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Section: Sle Generalitiesmentioning

confidence: 88%

Placental damage in pregnancies with systemic lupus erythematosus: A narrative review

Gutierrez

Figueras²,

Morales-Prieto³

et al. 2022

Front. Immunol.

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“…The pathogenesis of SLE is multifactorial always with the abnormal expression of molecules that are associated with the type I IFN signaling pathway [ 14 ]. In our study, the results of GO analysis revealed that the DEGs of SCLE were primarily enriched in the response to IFN-gamma, cellular response to IFN-gamma, and type I IFN signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…CCLE and SCLE are both common variants of CLE that may occur independently or as clinical manifestations of SLE [12,13]. Concern about the appearance of cutaneous rashes leads The pathogenesis of SLE is multifactorial always with the abnormal expression of molecules that are associated with the type I IFN signaling pathway [14]. In our study, the results of GO analysis revealed that the DEGs of SCLE were primarily enriched in the response to IFN-gamma, cellular response to IFN-gamma, and type I IFN signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Identification of Significant Genes and Pathways for the Chronic and Subacute Cutaneous Lupus Erythematosus via Bioinformatics Analysis

Teng

Ding

et al. 2022

Disease Markers

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Background. Chronic cutaneous lupus erythematosus (CCLE) and subacute cutaneous lupus erythematosus (SCLE) are both common variants of cutaneous lupus erythematosus (CLE) that mainly involve the skin and mucous membrane. Oral mucosal involvement is frequently observed in patients of CLE. Despite that they have different clinicopathological features, whether there is a significant difference in pathogenesis between them remains unclear. Herein, we investigated specific genes and pathways of SCLE and CCLE via bioinformatics analysis. Methods. Microarray expression datasets of GSE109248 and GSE112943 were both retrieved from the GEO database. Differentially expressed genes (DEGs) between CCLE or SCLE skin tissues and health controls were selected by GEO2R. Common DEGs were picked out via the Venn diagram software. Then, functional enrichment and PPI network analysis were conducted, and the top 10 key genes were identified via Cytohubba. Results. Totally, 176 DEGs of SCLE and 287 DEGs of CCLE were identified. The GO enrichment and KEGG analysis of DEGs of SCLE is significantly enriched in the response to virus, defense response to virus, response to IFN-gamma, cellular response to IFN-γ, type I IFN signaling pathway, chemokine activity, chemokine receptor binding, NOD-like receptor signaling pathway, etc. The GO enrichment and KEGG analysis of DEGs of CCLE is significantly enriched in the response to virus, regulation of multiorganism process, negative regulation of viral process, regulation of lymphocyte activation, chemokine receptor binding, CCR chemokine receptor binding, NOD-like receptor signaling pathway, etc. The top 10 hub genes of SCLE and CCLE, respectively, include STAT1, CXCL10, IRF7, ISG15, and RSAD2 and CXCL10, IRF7, IFIT3, CTLA4, and ISG15. Conclusion. Our finding suggests that SCLE and CCLE have the similar potential key genes and pathways and majority of them belong to IFN signatures and IFN signaling pathway. Besides, the NOD-like receptor signaling pathway might also have an essential role in the pathogenesis of SCLE and CCLE. Together, the identified genes and signaling pathways have enhanced our understanding of the mechanism underlying the occurrence and development of both SCLE and CCLE.

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“…This autoAb production results from an exacerbated IFN-I pathway that characterizes patients with systemic autoimmune diseases (SAD) [ 36 ] (Barturen et al, 2021) (Simon et al, 2021), and the presence of neutralizing anti–IFN–I autoAb lower disease activity as reported in SLE but not in RA [ 37 , 38 ]. Moreover, polymorphisms causing activation of the IFN-I pathway result in a phenotype, known as interferonopathy, which recapitulates some of the manifestations of lupus [ 39 ]. Due to the key role played by the IFN-I pathway in the physiopathology of SLE, the control of the circulating levels of IFN-I represents an interesting therapeutic option in SLE that could be exploited by targeting pDC (plasmacytoid dendritic cells) that secrete inappropriate levels of IFN-I (e.g.…”

Section: Innate Immune Response Against Sars-cov2mentioning

confidence: 99%

SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases

Larionova

Byvaltsev

Кравцова

et al. 2022

Journal of Translational Autoimmunity

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Abnormalities of the type I interferon signaling pathway in lupus autoimmunity

Cited by 47 publications

References 183 publications

Placental damage in pregnancies with systemic lupus erythematosus: A narrative review

Placental damage in pregnancies with systemic lupus erythematosus: A narrative review

Identification of Significant Genes and Pathways for the Chronic and Subacute Cutaneous Lupus Erythematosus via Bioinformatics Analysis

SARS-Cov2 acute and post-active infection in the context of autoimmune and chronic inflammatory diseases

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