ABO Blood Group and Risk of Coronary Heart Disease in Two Prospective Cohort Studies

Abstract

Objective Epidemiologic data regarding the association between ABO blood groups and risk of coronary heart disease (CHD) have been inconsistent. We sought to investigate the associations between ABO blood group and CHD risk in prospective cohort studies. Methods and Results Two large, prospective cohort studies (the Nurses’ Health Study [NHS] including 62,073 women and the Health Professionals Follow-up Study [HPFS] including 27, 428 men) were conducted with more than 20 years of follow-up (26 years in NHS and 24 years in HPFS). A meta-analysis was performed to summarize the associations from the present study and previous studies. In NHS, during 1,567,144 person-years of follow-up, 2,055 participants developed CHD; in HPFS, 2,015 participants developed CHD during 517,312 person-years of follow-up. ABO blood group was significantly associated with the risk of developing CHD in both women and men (log-rank test; P = 0.0048 and 0.0002 respectively). In the combined analysis adjusted for cardiovascular risk factors, compared with participants with blood group O, those with blood groups A, B or AB, were more likely to develop CHD (adjusted hazard ratios [95% CI] for incident CHD were 1.06 [ 0.99-1.15], 1.15 [ 1.04-1.26], and 1.23 [1.11-1.36]; respectively). Overall, 6.27% of the CHD cases were attributable to inheriting a non-O blood group. Meta-analysis indicated that non-O blood group had higher risk of CHD (RR= 1.11; 95% CI, 1.05 – 1.18; P = 0.001) compared with O blood group. Conclusions These data suggest that ABO blood group is significantly associated with CHD risk. Compared with other blood groups, those with the blood type O have moderately lower risk of developing CHD.

Distribution of ABO and Rhesus (Rh) blood group antigens in male type 2 diabetes mellitus patients in Hail region of Saudi Arabia: High incidences of diabetes mellitus in males with B+ blood type

“…However it is believed that individuals with certain blood types are more prone to get certain diseases. For example ABO blood antigens and Rhesus factors have previously been shown to be associated with the risk of stroke [17] and the coronary heart disease [18]. In some studies an increased frequency of diabetes mellitus was found in individuals with blood type B and a decreased frequency in people with AB blood type [19].…”

Grupo sanguíneo, alimentación y sobrepeso/obesidad: Una Miscelánea

“…Un total de 11 artículos fueron identificados en la búsqueda, cinco fueron científicos 11,12,13,14,15 de los cuales de eliminaron tres 11,12,13 por no incluir una de las tres variables y seis estudios teóricos 6,7,8,16,17,18 de los cuales se excluyeron dos 6,8 por no contar con los criterios de inclusión de la relación entre el grupo sanguíneo con al menos una de las dos variables (Figura 1.1).…”

“…Un estudio fue conducido solo en hombres el cual observó la relación del grupo sanguíneo y la OB en función de la exposición a la contaminación ambiental 14 . El estudio longitudinal contó con una muestra de 89,498 hombres y mujeres con 26 años de seguimiento en el cual observaron la relación entre el grupo sanguíneo tipo "A, B y AB", el desarrollo de OB y el riesgo de desarrollar enfermedad coronaria en presencia de contaminación ambiental 15 .…”

“…Otros autores concuerdan con esta teoría de alimentación de acuerdo al grupo sanguíneo que se tenga y que el consumo de aquellos alimentos no compatibles con su grupo sanguíneo potencializan el desarrollo de múltiples enfermedades 16 , infecciones, alergias 17 y falla de ciertos órganos como el corazón 14 y propician el SP y OB 7,15,18 .…”

“…Por su parte, los estudios científicos 14,15 relacionados al tema obtuvieron en sus hallazgos relaciones con el grupo sanguíneo y OB de manera contradictoria entre estos (Tabla 1.2).…”