ABO blood group discrepancies: Study of prevalence and related factors

Nepal, Bipin; Shrestha, Bikash; Maharjan, Sabindra; Bhasima, Sunil; Shrestha, Shrawan Kumar

doi:10.3126/gmj.v1i2.27059

Cited by 3 publications

(4 citation statements)

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“…Type II ABO discrepancy occurs because of an unpredicted reaction in cell grouping owing to diminished expression of the red cell antigens. 9 11 A weak subgroup of A is more common than a weak subgroup of B. Subgroups of A weaker than A2 contribute to almost 1% of ABO blood group discrepancy. 3 The subgroup of A can be broadly divided into two categories depending on the agglutination of red cells with anti-A.…”

Section: Discussionmentioning

confidence: 99%

“…Type I discrepancy characterizes by a diminished reaction in reverse grouping due to missing or weak antibodies. 9,11 Out of six cases, four donor samples had blood group discrepancy due to weak B antibodies, and the rest two samples had both anti-A and anti-B antibodies. The presence of weak B antibody is more common than the presence of anti-A antibody in type I ABO discrepancy.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Blood Group Discrepancy in Healthy Blood Donors at a Tertiary Care Referral Hospital from Eastern India: A Retrospective Study

et al. 2022

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Objective ABO typing constitutes cell grouping and serum grouping. The discrepancy may arise in ABO typing due to a mismatch in cell grouping and serum grouping. It may be due to technical errors, missing or weak ABO antibodies (type I), weak ABO subgroups (type II), Rouleaux formation (type III), or other miscellaneous reasons (type IV). This study was carried out to determine the prevalence and cause of ABO blood group discrepancy in donor samples at our center. Methods A retrospective study of ABO blood group typing of blood donors was conducted at our center. The blood group typing was routinely performed using gel cards and a microcentrifuge system (Tulip Diagnostics(P) Ltd, Goa, India). If any discrepancy in ABO typing was noted, the test was repeated using the conventional tube technique. After sorting clerical/technical error, the causes of discrepancy were analyzed and resolved using anti-A1, anti-H, anti-AB, and other immunohematological tests like antibody screening and identification, saliva inhibition test, adsorption-elution studies. Results A total of 12,715 (98.6% males and 1.4% females) donor samples were tested. The number of ABO discrepancies detected were 15 (0.12%). The discrepancies were characterized as type I (6 cases; 40%), type II (1 case; 6.7%), type III (0 cases; 0%), and type IV (8 cases; 53.3%). Three cases, each of anti-M and anti-Leb, were detected in the study population. A single case of A3, a subgroup of A blood group, was found during the study. Conclusion The prevalence of ABO group discrepancy was 0.12% at our center. Discrepancy arising during ABO typing of blood donor must be resolved before reporting ABO blood group to minimize the recipient's chances of transfusion reaction. The serum grouping is equally crucial as cell grouping for reporting the ABO group of an individual.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of Blood Group Discrepancy in Healthy Blood Donors at a Tertiary Care Referral Hospital from Eastern India: A Retrospective Study

et al. 2022

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“…16 Previous studies revealed that the most common responsible factor for ABO discrepancies was clerical errors including mixing-up of samples, identification and phlebotomy errors. 9,10 In present study we have omitted such cases. In our study, we found that frequent transfusions in cancer patients was a leading cause of ABO discrepancy followed by weakened expression of red cells antigens which were enhanced by lowering of temperature.…”

Section: Discussionmentioning

confidence: 99%

ABO discrepancy in pediatric lymphomas and solid organ tumors.

Saqlain

Mazher²,

Fateen³

et al. 2022

TPMJ

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Objective: To determine the frequency of ABO discrepancies in pediatric patients of lymphoma and solid organ tumors and to categorize these discrepancies and their resolution. Study Design: Cross-sectional study. Setting: Department of Hematology & Transfusion Medicine, The University of Child Health Sciences & The Children’s Hospital, Lahore. Period: November 2020 to September 2021. Material & Methods: ABO blood group discrepancies were assessed by tube method of blood grouping, using antisera A, B, AB & D for forward grouping and A, B, and O cells for reverse grouping. Auto control was also run. The resolution techniques were used accordingly. The collected data was checked for its completeness, consistency and accuracy before analysis which was done on SPSS version 26. Results: In this study, a total of 105 subjects were included with mean age of 5.64 ±2.1 years. Among them 72(68.6%) were male and 33(31.4%) were female. Out of total samples processed, three (2.9%) discrepancies found, 1 in female and 2 in male patients. There were two cases of Group I ABO discrepancies, one of which was resolved by elution, antibody screening and identification and other by incubation at 37oC and correlation with previous transfusion history. One case of Group II ABO discrepancy which was resolved by incubation at 40C for 30 minutes. Conclusion: This shows that ABO discrepancies occur in pediatric patients of lymphoma and solid organ tumors. So, the interpretation of forward and reverse ABO blood grouping, identification and resolution of ABO discrepancies in these patients should be done very carefully to avoid any transfusion related adverse reactions.

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“…In clinical emergencies , generally group O negative Red Blood Cells are transfused to save the life of patient . (4) Table 1 (5) : ABO Discrepancies are Classified Into Four Types.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Blood Grouping Discrepancies : Study From Tertiary Hospital based Blood Bank in Vadodara

Dogra¹,

Gosai²

2021

MLU

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Background:-ABO and Rhesus blood group system is considered as clinically significant blood group systems in transfusion practice . A feature of the ABO system is the regular occurrence of anti A and anti B in the absence of the corresponding red cell antigen. A Discrepancy exists when results of forward testing does not match with reverse testing. Blood donors and patients must be correctly ABO and Rh grouped because transfusing ABO incompatible blood transfusions which may lead even death of patient. Aims and ObjectivesTo assess the incidence and cause of blood grouping discrepancies in Blood Bank at Tertiary care teaching hospital during Jan 2019 to December 2019.Methods : Forward and reverse grouping were performed on blood samples from inpatients ,outpatients and donors during the study period. ABO discrepancies were studied with their clinical details to group their discrepancies and resolve them with suitable steps.Results: A total of 10,048 (patients and donors) who satisfied inclusion criteria were included and ABO typed among which there were 55 discrepancies were observed (15 donors and 35 patients). The problem in patients was due to expression of weak antigens. The problem in patients were due to clinical conditions, the most common being autoimmune haemolytic anaemia. Conclusions:The ABO blood group discrepancy reported in present study is 0.49%. The study helped to determine the incidence and causes of discrepancy encountered in tertiary care hospital. Discrepant results should be recorded, and resolved by suitable measures and correct ABO & Rh Blood group should be released to avoid any mismatched transfusions.

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ABO blood group discrepancies: Study of prevalence and related factors

Cited by 3 publications

References 5 publications

Analysis of Blood Group Discrepancy in Healthy Blood Donors at a Tertiary Care Referral Hospital from Eastern India: A Retrospective Study

Analysis of Blood Group Discrepancy in Healthy Blood Donors at a Tertiary Care Referral Hospital from Eastern India: A Retrospective Study

ABO discrepancy in pediatric lymphomas and solid organ tumors.

An Analysis of Blood Grouping Discrepancies : Study From Tertiary Hospital based Blood Bank in Vadodara

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