ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Abstract

Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI>1.4, prevalent PAD was defined as ABI≤ 0.9 at baseline and incident PAD as ABI≤0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p=0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17–2.35; p=0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.

Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status

“…In our analysis, the ABO blood groups were neither a relevant risk factor for IS nor PAD. Conversely, the MESA study showed that the A blood group was associated with a greater risk of PAD in African Americans, although it was not significant in Chinese, non-Hispanic white or Hispanic Americans [39]. Since our study was performed in a Caucasian Finnish population, race/ethnicity factors might be involved in the observed differences.…”

Grupos sanguíneos y su relación con los niveles plasmáticos del Factor de von Willebrand

“…Estudios han mostrado que los individuos con el grupo sanguíneo O están protegidos contra el Síndrome Coronario Agudo (SCA) debido a su propiedad de coagulación más baja, mientras que una de las causas de SCA en individuos del grupo sanguíneo tipo No-O, podría ser el aumento de las propiedades de coagulación por el incremento del FvW (55) . También se ha visto comprometido en riesgo de aterosclerosis, en donde un mecanismo que involucra al grupo sanguíneo en estos procesos, es que las glicosiltransferasas ABO impactan a las Moléculas de Adhesión Celular (CAM), que son proteínas que se expresan en el endotelio vascular y que reclutan gran cantidad de leucocitos en los procesos inflamatorios, conllevando a daños en la vasculatura y la consecuente formación de trombos, además el aumento de estas proteínas en circulación se ha asociado con enfermedad de la arteria coronaria, infarto de miocardio y aterosclerosis (56)(57)(58)(59) .…”

The association between ABO blood groups and TASC II classification in patients with peripheral artery disease

“…The frequency of atherosclerotic vascular disease was found to be increased in patients with blood groups other than group O. 6–8…”

“…The frequency of atherosclerotic vascular disease was found to be increased in patients with blood groups other than group O. [6][7][8] The TASC II classification is a widely used tool that shows the extent of atherosclerotic disease in the lower extremity and functions as a guide in the choice of treatment modality. In this classification, the disease is classified as TASC II A, B, C, and D considering severity of the disease.…”