ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility

Rizzo, Alicia N.; Schmidt, Eric P.

doi:10.1172/jci144075

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Additional studies have revealed that the expression of FUT1 is restricted to a limited extent within epithelial cells (37)(38)(39). The association between the expression of ABH antigens and inflammatory responses, including those induced by UV irradiation, breast and ovarian cancer, respiratory diseases, and pathogen infections, has been explored (33,(39)(40)(41)(42)(43). Despite this, the specific involvement of ABH antigens in skin diseases has remained largely elusive.…”

Section: Introductionmentioning

confidence: 99%

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Li,

Oh,

Suh

et al. 2024

Front. Immunol.

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The presence of the blood group H2 antigen on the membrane of red blood cells determines blood type O in individuals and this H2 antigen serves as a precursor to the A and B antigens expressed in blood types A and B, respectively. However, the specific involvement of ABH antigens in skin diseases is unknown. Therefore, we aim to investigate the expression of ABH antigens in skin tissue of patients with atopic dermatitis (AD) and MC903-induced AD-like mice. We demonstrated that the expression of ABH antigen is primarily located in the granular and horny layers of the skin in healthy control individuals. However, in patients with AD, the expression of the ABH antigen was absent or diminished in these layers, while the H2 antigen expression increased in the spinous layers of the affected skin lesions. Then, we investigated the biological function of blood group H antigen mediated by fucosyltransferase 1 (Fut1) in the skin, utilizing an AD mouse model induced by MC903 in wild-type (WT) and Fut1-knockout mice. After the application of MC903, Fut1-deficient mice, with no H2 antigen expression on their skin, exhibited more severe clinical signs, increased ear swelling, and elevated serum IgE levels compared with those of WT mice. Additionally, the MC903-induced thickening of both the epidermis and dermis was more pronounced in Fut1-deficient mice than that in WT mice. Furthermore, Fut1-deficient mice showed a significantly higher production of interleukin-4 (IL-4) and IL-6 in skin lesions compared with that of their WT counterparts. The expression of chemokines, particularly Ccl2 and Ccl8, was notably higher in Fut1-deficient mice compared with those of WT mice. The infiltration of CD4+ T cells, eosinophils, and mast cells into the lesional skin was significantly elevated in Fut1-deficient mice compared with that in WT mice. These findings demonstrate the protective role of H2 antigen expression against AD-like inflammation and highlight its potential therapeutic impact on AD through the regulation of blood group antigens.

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Section: Introductionmentioning

confidence: 99%

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Li,

Oh,

Suh

et al. 2024

Front. Immunol.

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“…They found that ABO gene mutations was significantly associated with individual thrombotic risk [6]. Several studies observed the associations of ABO blood group system with pregnancy related outcomes, including stillbirth [7] and obstetrical hemorrhage risk [8]. Additionally, pregnant women with type O blood had a lower risk of cardiovascular disease comparing to those with type A, type B and type AB [9].…”

Section: Introductionmentioning

confidence: 99%

The effect of protein levels of ABO on pregnancy related outcomes: a Mendelian randomization study

Sun,

Zheng,

Wang

et al. 2023

Preprint

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Protein level of Histo-Blood Group ABO System Transferase (ABO) has been reported to be associated with cardiometabolic diseases. But its effect on pregnancy related outcomes was still unclear. Here we conducted a two-sample Mendelian randomization study to ascertain the putative causal roles of protein levels of ABO in pregnancy related outcomes. Cis-acting protein quantitative trait loci (pQTLs) robustly associated with protein level of ABO (P<5x10-8) were used as instruments to proxy the ABO level (N=35,559, data from deCODE), with two additional pQTL datasets from Fenland (N=10,708) and INTERVAL (N=3,301) used as validation exposures. Ten pregnancy related diseases and complications were selected as outcomes. We observed that a higher protein level of ABO showed a putative causal effect on venous complications and haemorrhoids in pregnancy (OR=1.207, 95%CI=1.107-1.316, colocalization probability=91.3%), which was validated by using pQTLs from Fenland and INTERVAL. The Mendelian randomization results further showed effects of the ABO protein on gestational hypertension (OR=0.974, 95%CI=0.953-0.995), despite insignificance after multiple testing correction and little colocalization evidence. Sensitivity analyses, including proteome-wide Mendelian randomization of the cis-acting ABO pQTLs, showed little evidence of horizontal pleiotropy. Correctively, our study prioritised ABO as a putative causal protein for venous complications and haemorrhoids in pregnancy. Future epidemiology and clinical studies are needed to investigate whether ABO can be considered as a drug target to prevent adverse pregnancy outcomes.

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The effect of histo-blood group ABO system transferase (BGAT) on pregnancy related outcomes：A Mendelian randomization study

Sun,

Zheng,

Wang

et al. 2024

Computational and Structural Biotechnology Journal

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ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility

Cited by 5 publications

References 20 publications

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

The effect of protein levels of ABO on pregnancy related outcomes: a Mendelian randomization study

The effect of histo-blood group ABO system transferase (BGAT) on pregnancy related outcomes：A Mendelian randomization study

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