ABO blood types and postpartum depression among Chinese women: A prospective cohort study in Tianjin, China

Abstract

Postpartum depression is associated with adverse consequences for mother and offspring. The heritable ABO blood group has been associated with multiple diseases, including mental illness and diabetes. We explored the association of ABO blood group and postpartum depressive symptoms (PPDS) in a population-based cohort of pregnant Chinese women. From 2010 to August 2012, we recruited 8842 pregnant women with a mean age of 28.5 years (SD: 2.94) and mean body mass index of 22.4kg/m (SD: 3.45) in Tianjin, China. We used the Mainland Chinese version of the Edinburgh Postnatal Depression Scale after delivery with a cutoff score of 10 to define PPDS. Odds ratios (ORs) and 95% confidence intervals (CIs) for PPDS were obtained using binary logistic regression. Of 8842 women, 8.5% (n = 747) developed PPDS. Compared to those with blood group B, women with blood groups A, AB or O had a higher odds of PPDS (adjusted ORs: 1.23 (95% CI: 1.13-1.40), 1.31 (95% CI: 0.98-1.74), and 1.30(95% CI:1.03-1.60), respectively). Blood group B was associated with reduced odds of PPDS in pregnant Chinese women. If replicated in other studies, non-blood group B may be a useful risk factors for PPDS in Chinese pregnant women.

Correlation between Preoperative Anxiety and ABO Blood Types: Evidence from a Clinical Cross-Sectional Study

“…In the study of 108 normal volunteers, the results indicated the correlation between O blood type and depression [39]. A current trial of 8842 pregnant women reported that, in comparison to those with blood type B, patients with blood type O, A, or AB had a higher odds ratio of postpartum depression [36]. Additionally, past surveys established that mental anxiety with cardiovascular risk has also associated with ABO blood type [40].…”

Association of the ABO blood group with certain human diseases

“…Another study in China demonstrated that blood group B was associated with reduced odds of postpartum depressive symptoms (PPDS) in pregnant Chinese women. So non-blood group B may be a useful risk factor for PPDS in Chinese pregnant women [31] . Hence, scientists have found some clues that ABO may play an essential role in affective disorders.…”

Distribution of ABO Blood Groups and Their Association With Low Risk of Severe COVID-19 Infection in Patients

“…However, the blood type O may be a prognostic factor for patients with gastric cancer. The ABO blood group is also linked to the prognosis of various diseases [8,9,10,11], and prospective studies showed that the ABO blood group is associated with other diseases, which may be clinically signi cant [12,13,14]. Hence, we hypothesized that the ABO blood group would be associated with the risk of COVID -19 infection.…”