About Dendrimers:  Structure, Physical Properties, and Applications

Bosman, Anton W.; Janssen, Henk M.; Meijer, E. W.

doi:10.1021/cr970069y

Cited by 2,319 publications

(1,570 citation statements)

References 253 publications

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“…By virtue of these unique features, dendrimers are being recently studied for applications in gene therapy and as drug carriers and as contrast agents in imaging. 19,20 Poly(amidoamine) (PAMAM) 21 and poly(propylene imine) (PPI), 22 the commercially available dendrimers, have been widely studied for biological applications. As shown in Scheme 3, PAMAM dendrimers can have either amine or carboxylic groups and PPI dendrimers have amine groups on the periphery.…”

Section: Dendritic Micelles As Drug Delivery Vehiclesmentioning

confidence: 99%

Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery

2005

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This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric micelle-based approaches precede the work in dendrimers, these are also discussed briefly. The review concludes with a perspective on possible applications of biaryl-based dendrimeric micelles that exhibit environment-dependent conformations, in drug delivery.

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Section: Dendritic Micelles As Drug Delivery Vehiclesmentioning

confidence: 99%

Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery

2005

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“…29 One final point: both PAMAM and PPI dendrimers contain a statistical distribution of defects, mainly in the form of missing branches and loops. 2,30 Within the resolution of…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-Encapsulated Metal Nanoparticles: Synthesis, Characterization, and Applications to Catalysis

et al. 2000

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This Account reports the synthesis and characterization of dendrimer-encapsulated metal nanoparticles and their applications to catalysis. These materials are prepared by sequestering metal ions within dendrimers followed by chemical reduction to yield the corresponding zerovalent metal nanoparticle. The size of such particles depends on the number of metal ions initially loaded into the dendrimer. Intradendrimer hydrogenation and carbon-carbon coupling reactions in water, organic solvents, biphasic fluorous/ organic solvents, and supercritical CO 2 are also described.

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“…These polymeric architectures have been carefully studied since Vo¨gtle et al 3 reported the first concept of branching by repetitive growth and the first dendrimers were synthesized by Tomalia and co-workers at Dow Chemical in the early 1980s in parallel with Newkome's ''arborol'' systems. 4,5 The presence of a highly branched structure gives these polymers unique properties and it is foreseen that they will find use in specialized applications, for example; targeted drug-delivery, macromolecular carriers, enzyme-like catalysis, sensors, light harvesting, surface engineering and biomimetic applications. 2,4,6 Presently, there are over 10 000 scientific reports and 1000 patents dealing with dendritic structures.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 The presence of a highly branched structure gives these polymers unique properties and it is foreseen that they will find use in specialized applications, for example; targeted drug-delivery, macromolecular carriers, enzyme-like catalysis, sensors, light harvesting, surface engineering and biomimetic applications. 2,4,6 Presently, there are over 10 000 scientific reports and 1000 patents dealing with dendritic structures. Still, complex polymer structures, including dendritic materials, have struggled to be commercialized on a large scale by industry.…”

Section: Introductionmentioning

confidence: 99%