Abscess as Initial Presentation of Pure Primary Squamous Cell Carcinoma of the Breast

Gupta, Chakshu; Malani, Ashok K.

doi:10.1016/s1526-8209(11)70886-2

Cited by 15 publications

(18 citation statements)

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“…However, there are several reports of primary squamous cell carcinoma of the breast presenting as breast abscessesGupta et al, (5) Damin et al, (6) Tan et al (7) and Salemis et al (8) reported non-lactating breast abscesses in women aged 39 -70 years, whose primary squamous cell carcinomas of the breast were diagnosed using histologic examination of abscess walls. Primary squamous cell carcinoma of the breast is rare, accounting for less than 0.4% of all cases of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Primary squamous cell carcinoma of the breast is rare, accounting for less than 0.4% of all cases of breast cancer. (5) There are also reports of primary breast B-cell lymphoma that present with the initial clinical image of breast sepsis -Sun et al (9) and Antoniou et al (10) reported a unilateral and a bilateral case, respectively. The patients in those two reports did not harbour a typical abscess despite the highly inflammatory clinical features of the breast.…”

Section: Discussionmentioning

confidence: 99%

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Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Alipour

Seifollahi

Anbiaee

2013

smedj

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C a s e R e p o r t e247 I NTRO D U C TIO NInflammatory disorders of the breast, including mastitis and breast abscesses, are generally benign diseases that rarely harbour malignancy. Although the occurrence of cancer is not anticipated in true breast abscesses in nursing mothers, it can occasionally happen. Herein, we present a rare case of adenosquamous carcinoma of the breast in a 33-year-old lactating woman who presented with a breast abscess. CA S E R EPO RTA 33-year-old lactating woman presented to our breast clinic with signs of inflammation in her left breast -the skin was largely erythematous and warm over a tender 10-cm fluctuating mass, and several soft, non-suspicious lymphadenopathies were observed in the left axilla. According to the patient, the inflammation began two months prior to presentation and temporarily subsided with the use of oral antibiotics; when the use of oral antibiotics was discontinued, the inflammation flared up. Ultrasonography performed one month prior to presentation showed a multiloculated 93-mm × 82-mm × 63-mm fluidcontaining cavity in the left breast, which was suggestive of a breast abscess, and large reactive axillary lymph nodes in the same side.Intravenous antibiotics were prescribed, lactation ceased, and the cavity was surgically drained, yielding more than 300 mL of diluted pus. As routinely done in our institution, multiple biopsies were performed using the tissue obtained from the abscess wall. of the chest, abdomen and pelvis, and a bone scan of the whole body, was negative. The patient had no family history of breast cancer, and no other known risk factor was detected.Before proceeding with cancer treatment, we had to first determine whether the abscess was an inflammatory carcinoma or an invasive noninflammatory carcinoma presenting as an abscess. Although the inflammatory signs of the breast were in favour of the former diagnosis, a mismanaged large and persistent breast abscess is not uncommon in milk-laden breasts. Hence, the possibility of a lactating abscess superimposed on a typical invasive tumour was considered. However, since the pathologist who reviewed the histology slides could not detect any cancerous involvement in the dermal lymphatics, it was decided that the disease would be treated as a large noninflammatory invasive breast cancer.Following the diagnosis, the surgical wound was immediately closed to allow rapid initiation of neoadjuvant chemotherapy, which involved four cycles of treatment with cyclophosphamide, epirubicin and 5-fluorouracil, followed by four cycles of treatment with taxotere. As the patient did not consent to a mastectomy, breast-conserving surgery with a wide normal margin and axillary dissection was performed. The postoperative course was uneventful. Postoperative radiotherapy consisted of a 5,000-cGy breast and regional lymphatic area irradiation and a 1,000-cGy irradiation boost to the tumour bed. ABSTRACT We report the case of a 33-year-old lactating woman who presented with a 10-cm breast abscess.Biopsy of the abscess w...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Alipour

Seifollahi

Anbiaee

2013

smedj

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“…5 A systematic survey of indexed articles using the terms "epidermoid carcinoma of the breast" and "abscess" and using the terms "squamous cell carcinoma", "breast" were found in Medline ( Table 1). [5][6][7][8][9][10][11][12][13] A less specific survey using the terms "epidermoid carcinoma" and "breast (MeSH terms)" and using the terms "squamous cell carcinoma" and "breast (MeSH terms)" was also conducted. However, this proved to be less productive, since only five articles written in English since 1980 could be found.…”

Section: Discussionmentioning

confidence: 99%

“…PubMed "epidermoid carcinoma of the breast" AND "abscess" 8 case reports [5][6][7][8][9][10][11][12] No reviews of the literature "epidermoid carcinoma of the breast" AND "sepsis"…”

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confidence: 99%

Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

Damin¹,

Nascimento²,

Andreola³

et al. 2011

Sao Paulo Med. J.

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Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsisresUMo CONTEXTO: O carcinoma de células escamosas da mama é um câncer extremamente raro, representando cerca de 0,04% dos tumores malignos da mama. Até o momento, apenas um número limitado de casos da doença foi relatado, a maioria se apresentando clinicamente como um carcinoma de mama usual. RELATO DE CASO: Paciente feminina de 39 anos de idade se apresentando com grande abscesso de mama e sinais de sepse. Após debridamento cirúrgico da lesão, o exame histopatológico da cápsula do abscesso revelou a presença de carcinoma de células escamosas da mama. O tratamento definitivo do tumor foi uma mastectomia radical modificada com ressecção da lesão residual na mama direita. CONCLUSÃO: O presente caso, de apresentação incomum, demonstra como uma lesão aparentemente benigna, como um abscesso mamário, pode estar relacionada a uma neoplasia maligna oculta. Uma revisão da literatura a respeito do carcinoma de células escamosas de mama é apresentada.I MD, PhD. Attending Physician,

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Although its histogenesis is unclear, some authors suggest it may originate from complete metaplasia of ductal epithelium. [1,3,4,14] Development of SCC from metaplastic epithelium can also be considered as a complication of chronic breast inflammation, for example due to the presence of breast implants.…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma Of The Breast: A Case Report And Immunohistochemical Features For Differential Diagnosis

Temız¹,

Kandiloğlu²,

Şimşek³

et al. 2008

TUTFD

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Primary squamous cell carcinoma (SCC) of the breast is a rare tumor classified as one of the metaplastic carcinomas of the breast. Its incidence is less than 0.1% of all ductal carcinomas. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Its clinical features and radiological appearances are not specific. [3] We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass diagnosed with primary SCC of the breast. We have discussed immunohistochemical features of this rare tumor with respect to its differential diagnosis from invasive ductal Sağ memesinde hızlı büyüyen kitle yakınmasıyla başvuran 68 yaşında postmenopozal kadın hastaya tru-cut biyopsisi, lezyonun infiltratif yapısı ve immunohistokimyasal olarak c-erbB-2 (HER2/neu) ve progesteron reseptör pozitifliğine dayanarak "invaziv duktal karsinom" tanısı kondu. Hasta dört kür kemoterapiye (adriyamisin ve siklofosfamid) kısmi yanıt verdi. Kemoterapi sonrası modifiye radikal mastektomi ve aksiller lenf nodu diseksiyonu (level III) uygulandı. Makroskopik olarak üst iç ve dış kadranda 5 cm çaplı, kirli beyaz, solid, düzensiz sınırlı, merkezi kısmı nekrotik ve hemorajik tümör saptandı. Mikroskopik olarak kötü diferansiye skuamöz hücreli karsinom (SCC) niteliğindeki tümör çevresinde skuamöz metaplazili intraduktal epitelial hiperplazi ve multipl küçük SCC odakları gözlendi. Tümör, kemoterapiye bağlı regresyonu yansıtan nekrotik, hemorajik ve fibrotik alanlar içermekte idi. Deri tutulumu izlenmedi. İmmunohistokimyasal olarak tümörde CK7, CK8, CK19, HMW-CK ve E-cadherin diffüz, CEA fokal pozitifti. Östrojen ve progesteron reseptörleri ve c-erbB-2 negatifti. Materyalden ayıklanan 20 lenf nodundan beşi metastatikti. Klinik olartak skuamöz hücreli karsinomun gelişebileceği diğer organlar tarandı ve başka bir yerde herhangi bir tümör görülmedi. Operasyon sonrası oral kemoterapi (kapesitabin) alan hasta, bir yıldır sağlıklı bir şekilde yaşamını sürdürmektedir.Anahtar sözcükler: Primer skuamöz hücreli karsinom; meme; immunohistokimya; ayırıcı tanı.We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass. It was diagnosed as "invasive ductal carcinoma" on tru-cut biopsy owing to infiltrative pattern and c-erbB-2 (HER2/neu) and progesterone receptor positivities. Partial response was obtained after four cure chemotherapy (adriamycin and cyclophosphamide). Then, she underwent a modified radical mastectomy with axillary lymph node dissection (level III). Grossly, a white-tan, solid, ill-defined tumor with 5 cm diameter located in the upper inner and outer quadrant of the breast was detected. Central portion of the tumor showed necrotic and hemorrhagic changes. Microscopic examination revealed poorly differentiated squamous cell carcinoma (SCC) having intraductal epithelial hyperplasia with squamous cell metaplasia and multiple small tumor foci at the periphery. The tumor had patchy necrotic, hemorrhagic and fibrotic areas representing regressive changes due to chemotherapy effect. Immunohistochemically, the t...

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Abscess as Initial Presentation of Pure Primary Squamous Cell Carcinoma of the Breast

Cited by 15 publications

References 3 publications

Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

Primary Squamous Cell Carcinoma Of The Breast: A Case Report And Immunohistochemical Features For Differential Diagnosis

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