Absence epilepsy and the level of vigilance in rats of the WAG/Rij strain

Coenen, A.M.L.; Drinkenburg, Wilhelmus; Peeters, B.W.M.M.; Vossen, J.M.H.; Luijtelaar, E.L.J.M. van

doi:10.1016/s0149-7634(05)80005-3

Cited by 121 publications

(63 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Earlier data clearly showed that bicuculline produces a dose-dependent behavioral activation such as crossing, grooming, rearing, and running when microinjected into the hypothalamus (29,30). As different investigators have pointed out, active behavior is unfavorable for the occurrence of spikewave discharges and causes a decrease in their occurrence (31)(32)(33). Moreover, Peeters et al (34) demonstrated that intracerebroventricular administration of bicuculline inhibits spike-wave activity and, in contrast, activation of GABA A receptors by muscimol causes a dose-dependent increase in the number of spike-wave complexes (34).…”

Section: Figmentioning

confidence: 99%

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat

Aker

Onat

2002

Epilepsia

View full text Add to dashboard Cite

Summary:Purpose: ␥-Aminobutyric acid (GABA) plays a vital role in both central cardiovascular homeostasis and pathogenesis of epilepsy. Epilepsy affects autonomic nervous system functions. In this study, we aimed to clarify the role of GABA A receptors in hypothalamic cardiovascular regulation in a genetically determined animal model of absence epilepsy.Methods: Nonepileptic Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) were instrumented with a guide cannula for drug injection and extradural electrodes for EEG recording. After a recovery period, iliac arterial catheters were inserted for direct measurement of mean arterial pressure and heart rate. Bicuculline, a GABA A -receptor antagonist, was injected into the dorsomedial (DMH) or posterior (PH) hypothalamic nuclei of nonepileptic control rats or GAERS. Blood pressure, heart rate, and EEG recordings were performed in conscious unrestrained animals.Results: Bicuculline injections into the hypothalamus produced increases in blood pressure and heart rate of both control rats and GAERS. The DMH group of GAERS showed a twofold increase in the blood pressure and the heart rate compared with those of control rats. Pressor responses to bicuculline, when microinjected into the PH, were similar in the nonepileptic animals and GAERS. Conversely, the amplitude of tachycardic responses to the administration of bicuculline into the PH was significantly higher in GAERS compared with those of control rats. Conclusions:The bicuculline-induced increases in blood pressure and heart rate were more prominent when given in the DMH of GAERS. These results indicate an increased GABA A receptor-mediated cardiovascular response through the DMH in conscious rats with absence epilepsy.

show abstract

Section: Figmentioning

confidence: 99%

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat

Aker

Onat

2002

Epilepsia

View full text Add to dashboard Cite

show abstract

“…Sexual behavior and ultrasonic vocalizations at the 50-kHz band are ethological correlations of reward system functioning -in WAG/Rij rats, both are poorly described. Some data suggest that reproductive behavior is normal in these rats [4,5], but if male WAG/Rij rats show depressive-like symptoms, we should expect some deficit in their sexual behavior similar to the deficit observed in the sexual activity of humans with depression. In this case, we decided to investigate more closely the sexual behavior of these rats with additional analysis of ultrasonic vocalizations at the 50-kHz band (precontact ultrasonic vocalizations) as well as at the 22-kHz band (postejaculatory vocalizations).…”

Section: Introductionmentioning

confidence: 81%

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Bialy

Strefnel

Nikolaev-Diak

et al. 2014

Epilepsy & Behavior

View full text Add to dashboard Cite

“…This increase manifests itself within 1 h after injection and persists 4 to 10 h [28]. Considering the intimate relationship between the relative amount of passive behavior (including drowsiness and light slow-wave sleep) and the number of SWDs [41], it is possible that a rise in SWDs found after administration of IL-1β is due to an increase in passive behavior and/or sleep. We have no behavioral data during the light episode.…”

Section: Discussionmentioning

confidence: 99%

Cytokines and Absence Seizures in a Genetic Rat Model

et al. 2012

View full text Add to dashboard Cite

We investigated the role of two cytokines, IL-1β and TNF-α, in the development of absence seizures using a genetic model of absence epilepsy in WAG/Rij rats. We administered these cytokines to animals systemically and measured the number of spike-wave discharges (SWDs) in the EEG. We also coadministered IL-1β with the GABA reuptake inhibitor tiagabine and measured the levels of IL-1β and TNF-α in the brain and blood plasma of 2-, 4-, and 6-month-old WAG/Rij rats and animals that served as a non-epileptic control (ACI). We found that IL-1β induced a significant increase in SWDs 2-5 h after administration, while TNF-α enhanced SWDs much later. Both cytokines enhanced passive behavior; body temperature was elevated only after TNF-α. The action of tiagabine was potentiated by earlier IL-1β injection, even when IL-1β was no longer active. Young WAG/Rij rats showed higher levels of TNF-α in blood serum than young ACI rats; the effects in the brain tended to be opposite. The marked differences in timing of the increase in SWDs suggest different time scales for the action of both cytokines tested. It is proposed that the results found after TNF-α are due to the de novo synthesis of IL-1β. TNF-α may possess neuroprotective effects. IL-1β might increase GABAergic neurotransmission. The changes in the efficacy of antiepileptic drugs related to changes in the cytokine systems may have some clinical relevance.

show abstract

Absence epilepsy and the level of vigilance in rats of the WAG/Rij strain

Cited by 121 publications

References 25 publications

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Cytokines and Absence Seizures in a Genetic Rat Model

Contact Info

Product

Resources

About

Absence epilepsy and the level of vigilance in rats of the WAG/Rij strain

Cited by 121 publications

References 25 publications

Cardiovascular Regulation through Hypothalamic GABAA Receptors in a Genetic Absence Epilepsy Model in Rat

Cardiovascular Regulation through Hypothalamic GABAA Receptors in a Genetic Absence Epilepsy Model in Rat

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Cytokines and Absence Seizures in a Genetic Rat Model

Contact Info

Product

Resources

About

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat

Cardiovascular Regulation through Hypothalamic GABA_A Receptors in a Genetic Absence Epilepsy Model in Rat