Absence of a factor blocking a cellular cytotoxicity reaction with serum of women with recurrent abortion

Lymphocyte Immunization Generates Immunosuppressive Factors in Women with Recurrent Abortions

“…A serum component also inhibited a cellular cyto toxicity reaction and absorption assays imply it might be P4 protein present in the serum during normal preg nancy [14]. This protein has been shown to be able to modify nonspecifically mixed lymphocytes reaction and cellular cytotoxicity if cells are incubated with P4 ex tracts before the test [12].…”

“…Lym phocyte injection would stimulate the response of the women and then blocking factors as P4 protein may appear. This protein (P4), which inhibits cellular cyto toxicity, is inactive in the serum of women with recur rent abortions [12]. This factor seems necessary for the maintenance of the fetal allograft.…”

“…These blocking antibodies are normally demonstrable in women's serum during normal preg nancy and are usually absent from habitual abortions [12,20]. Blood transfusions could stimulate their ap pearance [20][21][22], With regard to nonspecific inhibition of MLR, i.e.…”

“…Pregnancy constitutes a peculiar example where we observe the immunological accep tance of the fetal allograft. To explain this situation, var ious immunosuppressive factors have been identified in the serum of pregnant women; their activity could be specific [4][5][6][7][8][9] or nonspecific of fetal antigens [10][11][12][13][14], We have described the 'P4' protein which inhibits a cel lular cytotoxicity reaction [14]. Several factors lead us to think that some recurrent abortions have an immunolog ical cause [13] and research in reproductive biology leads to the concept that implantation requires maternal im munological recognition of fetus antigens; failure of rec ognition or an inappropriate response is associated with pregnancy failure.…”

Avortements d'origine immunologique

“…Ces facteurs sont nombreux, citons : les hormones et notamment la progestérone et l'hCG et d'autres protéines associées à la grossesse qui possèdent in vitro une action inhibitrice de la transformation lymphoblastique ou de la cytotoxicité cellulaire (Fizet et Bousquet, 1983 (Chaouat, 1987 …”