Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin in rats

Abstract

Sesamin was absorbed efficiently and distributed over the whole body. In particular, sesamin was highly distributed in the form of the metabolites in the liver and kidney. The results of this study are useful in elucidating the action mechanism of sesamin.

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

“…e previous study of Umeda-Sawada demonstrated the sesamin can be detected in rat's brain after oral administration of sesamin at 0.5% (w/w) by high-performance liquid chromatography (HPLC). In the [20]. In addition, there are other reports that confirm the blood-brain barrier permeability of sesamin.…”

Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study

“…A neuroprotective effect was also exhibited in gerbil brain in cerebral ischemia [ 52 ]. Sesamin was absorbed efficiently and distributed throughout the whole body, especially in the liver and kidney in the form of its metabolites [ 21 ]. The difference between astaxanthin and sesamin in distribution throughout the body may contribute to the anti-fatigue effect of AS.…”

“…An adequate wash out period was determined as four weeks between first and second test periods, which is >5 half-lives of astaxanthin and sesamin. The half-lives of astaxanthin and sesamin are reported as between 12 and 22 h [ 19 , 20 ] and about 4.7 h, respectively [ 21 ]. Participants were instructed to maintain their regular diet and not to consume an excessive amount of food and alcoholic beverages.…”

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

“…The conversion of sesamin into catechol derivatives and converted further into glucuronides or sulfates in the liver [70][71][72][73] has been reported to have anti-inflammatory effect on macrophage cell line (J774.1 cells). The said sesamin metabolites have been reported to have strong inhibitory effects on the LPS-induced NO production [74]. Through methylation, the catechol group of the sesamin metabolites was found to cause this inhibition.…”