2017
DOI: 10.1158/1538-7445.am2017-1319
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Abstract 1319: Epigenome-wide association study reveals differential DNA methylation consistent with progression of multiple myeloma

Abstract: Purpose: Multiple myeloma (MM) is the second most common hematological malignancy in the US. It is characterized by a clonal expansion of plasma cells in the bone marrow and extramedullary sites and is preceded by two precursor conditions including monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). Strong evidence suggests a germline and environmental etiology. However, efforts to characterize heritable changes in gene activity, such as DNA methylation, have not been widely… Show more

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