2022
DOI: 10.1158/1538-7445.am2022-1497
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Abstract 1497: miRNA expression analysis in high-risk HPV-positive cervical scrapes for the detection of cervical disease

Abstract: Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women, with an estimated 604,000 new cases and 342,000 deaths worldwide in 2020. Persistent infections with high-risk HPV (hrHPV) genotypes can lead to high-grade lesions (Cervical Intraepithelial Neoplasia Grade 2 or higher, CIN2+), that if left untreated progress to cancer. hrHPV test has high sensitivity to detect CIN2+, but it has low specificity because close to 90% of women spontaneously clear t… Show more

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