2019
DOI: 10.1161/res.125.suppl_1.235
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Abstract 235: A Micropeptide Regulator of Voltage-gated Potassium Channels Controls Cardiac Rhythm

Abstract: Voltage-gated potassium (K + ) channels (VGKCs) are essential regulators of the cardiac action potential and are required to maintain normal heart rhythm and contractility. Voltage-dependent activation, conductance and membrane trafficking of K + channels are tightly controlled by a family of single transmembrane regulatory cofactors (KCNE1-5), which co-assemble with pore forming K + channels in cell membranes. Human mutations in voltage-g… Show more

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