Abstract:Cachexia is the unintentional loss of skeletal muscle and adipose tissue. Over 80% of patients with pancreatic adenocarcinoma cancer (PDAC) suffer from cachexia, resulting in reduced survival and quality of life. The magnitude of adipose loss is often greater than muscle loss in patients and animal models. Our prior work in a mouse model of orthotopic PDAC cachexia revealed alterations of multiple pathways in adipose, predominantly inflammation, cytokine signaling, and metabolism. Deconvolution analysis predic… Show more
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