2023
DOI: 10.1158/1538-7445.am2023-360
|View full text |Cite
|
Sign up to set email alerts
|

Abstract 360: Changes in adipose tissue microenvironment occurs early in murine models of pancreatic cancer cachexia

Abstract: Cachexia is the unintentional loss of skeletal muscle and adipose tissue. Over 80% of patients with pancreatic adenocarcinoma cancer (PDAC) suffer from cachexia, resulting in reduced survival and quality of life. The magnitude of adipose loss is often greater than muscle loss in patients and animal models. Our prior work in a mouse model of orthotopic PDAC cachexia revealed alterations of multiple pathways in adipose, predominantly inflammation, cytokine signaling, and metabolism. Deconvolution analysis predic… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles