2012
DOI: 10.1158/1538-7445.am2012-4943
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Abstract 4943: Genetically engineered osteoprotegerin for multiple myeloma osteolytic bone damage

Abstract: Current treatments for osteolytic cancers include a combination of radiation, chemotherapy and cytotoxic products, but toxic side effects are still of major concern. Studies have shown that osteoclast activity is increased in patients with osteolytic cancers such as Multiple Myeloma (MM), through increased expression of Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) leading to RANKL/RANK signaling, resulting in osteoclast activation and ultimately bone resorption. Moreover, Osteoprotegerin (OPG) i… Show more

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