2016
DOI: 10.1158/1538-7445.am2016-527
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Abstract 527: Myeloid PTEN deficiency impairs tumor immune surveillance via immune checkpoint inhibition

Abstract: In the current study we are investigating the effects of PTEN-deficient myeloid cells on tumor immune surveillance. We could previously show that hyper-activation of the PI3K signaling cascade by genetic knock-out of the counteracting phosphatase PTEN induced an anti-inflammatory phenotype in myeloid cells. This resulted in protection of conditional knock-out mice in models of acute infection and inflammation. A reduction in pro-inflammatory responses could however increase tumor burden. To addr… Show more

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