Abstract:Introduction
Nearly 45% of colorectal cancer (CRC) patients harbor a mutation in their KRAS gene for which, despite many years of research, there are still no targeted therapies available. Protein Arginine Methyltransferase 5 (PRMT5) is a transcription regulator for multiple cellular processes that is currently being tested as a potential therapeutic target in several cancer types. Previous studies have shown that PRMT5 depletion leads to a reduction in FGFR3 and eIF4E expression. FGFR3 and eIF4… Show more
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