Abstract:Studies with Diethylstilbestrol (DES) in humans and rodents have resulted in a spectrum of toxic and carcinogenic effects. Previous findings on gene expression profiles following DES treatment showed that p53, p21 and bax was transcriptionally regulated in this model. In the present studies,Reverse Transcriptase in situ Polymerase Chain Reaction and immunohistochemistry techniques for localization and expression of p53, p21 and bax at cellular levels was applied. Animal were housed individually and treated wit… Show more
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