2013
DOI: 10.1158/1538-7445.fbcr13-b41
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Abstract B41: EMC1 influences cellular calcium homeostasis and promotes breast cancer cell migration and proliferation

Abstract: Endoplasmic Reticulum Membrane Complex protein 1 (EMC1), also named KIAA0090, was recently identified as part of a complex with six proteins (EMC1-EMC6) proposed to participate in the folding/maturation of membrane proteins, but the mechanisms remains unclear. High throughput studies reveal that EMC1 gene is up-regulated in many types of cancer and up-regulation correlates to poor survival rates. It has been known that there is a close relationship between proteins involved in the unfolded protein response (UP… Show more

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