2014
DOI: 10.1161/circ.129.suppl_1.p281
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Abstract P281: A Novel Mutation in Adiponectin Receptor 1 Contributes to Cardiac Hypertrophy and Cardiometabolic Dysregulation

Abstract: Adiponectin, an adipocyte-derived cytokine, is known to influence cardiac remodeling and to suppress pathological cardiac growth and diabetes-induced disorders. Disruption of adiponectin or its receptor AdipoR1 has significant effects on cardiomyocyte hypertrophy and myocardial metabolism signal transduction. We recently identified a novel mutation in the AdipoR1 gene among 126 hypertrophic cardiomyopathy patients, including two family members with diabetes. Our screening identified a G>A transition at 146t… Show more

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