Abstract: P4HB: The Ideal Mesh for Complex Abdominal Wall Reconstruction?

Levy, Adam; Bogue, Jarrod T; Morrison, Kerry A.; Lieberman, Michael D.; Pomp, Alfons; Spector, Jason A.

doi:10.1097/01.gox.0000503029.34342.78

Cited by 2 publications

(2 citation statements)

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“…LTBA formed using a degradable biosynthetic polymer is designed to leverage the benefits and minimise the deficiencies of existing synthetic and biologic mesh types [4, 5]. There are several terms to describe this mesh, including ‘absorbable synthetic mesh’, ‘resorbable synthetic mesh’, ‘absorbable biosynthetic surgical mesh’, and ‘biosynthetic mesh’.…”

Section: Introductionmentioning

confidence: 99%

Establishing Peer Consensus About the Use of Long‐Term Biosynthetic Absorbable Mesh for Hernia (Grades 2–3) as the Standard of Care

et al. 2022

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Background Standard synthetic and biologic meshes, often used in hernia repair, have commonly been used and each have their strengths but associated drawbacks. Long‐term biosynthetic absorbable (LTBA) mesh has been developed to combine the strengths of synthetic and biologic meshes without the associated weaknesses. As a newer type of mesh, the supporting evidence base is still growing, and their optimum use has yet to be defined. This consensus was initiated to provide insight into those situations where a LTBA might be considered the Standard of Care in ventral hernia repair grades 2–3 (original classification, 2010) of the Ventral Hernia Working Group. Methods A steering group of expert surgeons identified 35 statements, based around the evidence supporting LTBA, surgical technique, patients type most suitable for LTBA, risk–benefit of LTBA, patient and surgeon considerations, LTBA value. Surgeons involved in hernia repair received an online survey to assess consensus with these statements. Consensus was defined as high if ≥ 70% and very high if ≥ 90% of respondents agreed. Statements that had not achieved consensus agreement were revised and these were then issued for a subsequent round. Finally, 34 statements were included. Results Two hundred fifty‐five surgeons were involved. Fourteen statements (41%) achieved very high consensus, 24 achieved consensuses (≥ 70–< 90%), whilst one (3%) just failed to achieve consensus with an agreement score of 69%. Conclusions Expert consensus opinion about the use of LTBA for hernia (Grades 2–3) as the Standard of Care was achieved. Based on the consensus scores, the steering group derived eleven keys.

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Section: Introductionmentioning

confidence: 99%

Establishing Peer Consensus About the Use of Long‐Term Biosynthetic Absorbable Mesh for Hernia (Grades 2–3) as the Standard of Care

et al. 2022

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“…For instance, P4HB has been commercialized by Tornier as the first orthopedic soft tissue scaffold for tendon repair (BioFiber®, 7 ). P4HB has also been employed in the production of P4HB meshes for hernia repair (Phasix®, 8,9 ) and plastic and reconstructive surgeries (GalaFLEX®, 10 ).…”

Section: Introductionmentioning

confidence: 99%

Electrospun scaffolds for wound healing applications from poly(4‐hydroxybutyrate): A biobased and biodegradable linear polymer with high elastomeric properties

Keridou

Franco

Martínez

et al. 2021

J of Applied Polymer Sci

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Electrospun scaffolds of the biodegradable and biocompatible poly‐4‐hydroxybutyrate (P4HB) polyester have been prepared using horizontal and vertical set‐up configurations of electrospinning. Specifically, it has been evaluated the influence of solvent, polymer concentration, and processing parameters, such as applied voltage, flow rate, and needle tip‐collector distance. Scaffolds obtained under the most favorable conditions were characterized in terms of crystallinity, lamellar supramolecular order, thermal (including calorimetric and thermogravimetric data), mechanical, and surface properties. Results pointed out significant differences with respect to commercial sutures (based in P4HB, e.g., MonoMax®) and demonstrated that electrospun scaffolds were constituted by crystalline microfibers with a tangled distribution that leads to high modulus Young modulus (4 MPa), maximum strength (28 MPa), and elongation (360%). Furthermore, new scaffolds had thermal stability and a rough surface that led to a hydrophobic character (105°). Scaffolds could also be successfully loaded during the electrospinning process with a peptide analog to the fibroblast growth factor (e.g., CYRSRKYSSWYVALKRC), giving rise to fully biocompatible samples with a clear acceleration in wound healing.

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Abstract: P4HB: The Ideal Mesh for Complex Abdominal Wall Reconstruction?

Cited by 2 publications

References 0 publications

Establishing Peer Consensus About the Use of Long‐Term Biosynthetic Absorbable Mesh for Hernia (Grades 2–3) as the Standard of Care

Establishing Peer Consensus About the Use of Long‐Term Biosynthetic Absorbable Mesh for Hernia (Grades 2–3) as the Standard of Care

Electrospun scaffolds for wound healing applications from poly(4‐hydroxybutyrate): A biobased and biodegradable linear polymer with high elastomeric properties

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