Abstract:Inherited genetic variants are estimated to account for 30-35% of overall breast cancer risk. A few rare, highly penetrant, genetic determinants of risk in humans have been well defined. However, the actions of many common weakly penetrant breast cancer risk loci remain uncharacterized. Additionally, it is well established that endocrine factors in general, and estrogens in particular, influence breast cancer etiology. We are using the ACI rat model of 17β-estradiol (E2)-induced mammary cancer to parse the con… Show more
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