Abu Dhabi third stage trial: oxytocin versus Syntometrine in the active management of the third stage of labour

Khan, G. Q.; Imaralu, John; Chan, Teresa M.; Wani, Salima; Stirrat, Gordon M.

doi:10.1016/0028-2243(95)80014-j

Cited by 29 publications

(18 citation statements)

References 14 publications

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“…Blood loss was estimated subjectively by the attendant midwife or obstetrician, as in other randomised trials of the prevention of postpartum haemorrhage 6,27–33 . Postpartum haemorrhage was defined as estimated blood loss > 500 mL, and severe postpartum haemorrhage as estimated blood loss > 1000 mL.…”

Section: Methodsmentioning

confidence: 99%

The misoprostol third stage of labour study: a randomised controlled comparison between orally administered misoprostol and standard management

El-Refaey

Nooh

O’Brien

et al. 2000

BJOG

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Objective To compare misoprostol with standard oxytocic regimens in the prevention of postpartum Design Randomised controlled trial.Setting Obstetric unit in a large teaching hospital.Methods One thousand women randomised to 500 pg misoprostol given orally or to standard oxytocic regimens of oxytocin, oxytocin with ergometrine, or ergometrine. Main outcome measuresIncidence of postpartum haemorrhage and the incidence and severity of side effects.Results Postpartum haemorrhage occurred in 12% of women given misoprostol and in 11% of women given standard oxytocic drugs (relative risk (RR) 1.10, 95% confidence interval (CI) 0.79, 1.55). Blood loss of 1000 mL or more occurred in 2% of women in each group. Nausea, headache, dizziness and tiredness were less frequent with misoprostol (RR (95% CI) 0.71 (0.59,0434); 0.53 (0.38,0.74); 0.73 (0.61,0.87) and 0.88 (0.83, 0.94) respectively). The main side effects of misoprostol were shivering (RR 1.95,95% CI 1-69,2.25) and a rise in temperature (difference in mean rise 0-34OC, 95% CI ConclusionOral misoprostol for the prevention of postpartum haemorrhage was comparable to standard oxytocics. Many side effects were less common with misoprostol but shivering and pyrexia were more common. Larger randomised trials are needed before establishing the equivalence between misoprostol and standard oxytocic drugs in the prevention of postpartum haemorrhage.haemorrhage. 0*26,0*42).

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Section: Methodsmentioning

confidence: 99%

The misoprostol third stage of labour study: a randomised controlled comparison between orally administered misoprostol and standard management

El-Refaey

Nooh

O’Brien

et al. 2000

BJOG

View full text Add to dashboard Cite

show abstract

“…There is disagreement about the overall relative effectiveness of Syntometrine and oxytocin as third stage uterotonics . A recent Cochrane review, summarising six trials, concluded that Syntometrine was modestly more effective than oxytocin (in either 5 IU or 10 IU IM or intravenous (IV) bolus) in the prevention of PPH .…”

Section: Discussionmentioning

confidence: 99%

“…For example, three different oxytocin regimens have been compared with Syntometrine: 5 IU IM oxytocin, 10 IU IV and 10 IU IM . We used 10 IU IM.…”

Section: Discussionmentioning

confidence: 99%

“…While trial populations were evenly balanced for the intervention and control arms within each trial, populations were not comparable across trials. All trials included women with singleton pregnancies but one trial included only women who gave birth spontaneously, while another included participants who delivered via emergency caesarean section and instrumental delivery . All trials except that reported by Khan et al .…”

Section: Discussionmentioning

confidence: 99%

“…excluded women who they considered would require an oxytocin infusion postpartum (parity >4, uterine fibroids). Khan et al . excluded women with significant risk factors, including pre‐existing anaemia, operative delivery and multiple pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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