Abundant tannic acid modified gelatin/sodium alginate biocomposite hydrogels with high toughness, antifreezing, antioxidant and antibacterial properties

Zhang, Xiumei; Liu, Kejun; Miao, Qiguang; Lan, Weiwei; Wang, Long; Liang, Ziwei; Li, Xiaochun; Wei, Yan; Hu, Yinchun; Zhao, Liqin; Lian, Xiaojie; Huang, Di

doi:10.1016/j.carbpol.2023.120702

Cited by 54 publications

(15 citation statements)

References 46 publications

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“…Bacterial infection often occurs in wounds, so antibacterial property is valuable to tissue adhesive. , TA has broad-spectrum antibacterial activity and can kill both Gram-positive and Gram-negative bacteria by disrupting the expression of proteins of cell walls and cytomembranes . WrITA was cultured with bacteria solution.…”

Section: Resultsmentioning

confidence: 99%

Injectable, Water-Reinforceable, and Antibacterial Tissue Adhesive with Underwater Bioadhesion Capability

Huang,

Xu,

Fang

et al. 2023

Chem. Mater.

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It is challenging for adhesives to adhere to tissues covered with body fluids as the hydration layer hinders adhesive/tissue interfacial interactions. Marine creature mussels can firmly adhere to underwater reefs by the coacervate adhesive composed of mussel foot proteins (Mfps). Inspired by these water-reinforceable Mfps extruded from byssus, an injectable and water-reinforceable tissue adhesive (WrITA) was developed in this work. It is composed of poly(acrylic acid-co-N-vinylpyrrolidone) (poly(AAc-co-NVP)), tannic acid conjugated poly(lipoic acid) (TA-c-PLA), and polyethylenimine. Upon contacting with water, hydrophobic PLA chains of TA-c-PLA in WrITA formed a self-associated cross-linking point, which induced contraction of the poly(AAc-co-NVP) network due to multiple hydrogen bonds between TA and poly(AAc-co-NVP) chains. In this process, the cohesive strength of the adhesive was enhanced, which could provide a tough base for durable underwater tissue adhesion. In underwater adhesion, the hydrophobic PLA chains could evict interfacial water to facilitate the interfacial adhesion via electrostatic interactions and hydrogen bonds. WrITA could form tight adhesion to the tissue in minutes. Its lap-shear adhesion strength reached 87 kPa after 3 min of curing but increased and remained at 100 kPa after 3 h on porcine skin underwater. In addition, its bursting pressure on porcine skin was up to 1912 mmHg. In addition to the strong underwater tissue adhesion, it also had superior antibacterial and antioxidant activity, as well as cytocompatibility. The easy-to-use and safe WrITA may meet the need for quick deployment underwater in diverse biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Injectable, Water-Reinforceable, and Antibacterial Tissue Adhesive with Underwater Bioadhesion Capability

Huang,

Xu,

Fang

et al. 2023

Chem. Mater.

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“…By adding only 0.4 wt % TA, the value of G ′ at 25 °C increases from 485.3 to 892.7 MPa, the fracture strain increases from 430 to 1739%, and the tensile stress simultaneously changes from 3.5 to 9.3 MPa. This prominent strengthening effect of TA can be ascribed to the formation of hydrogen bonds formed between the phenolic hydroxyl groups in TA, the hydroxyl groups in SA, and the ether bonds in PEO. – The Raman spectra of PEO/SA composites with or without TA addition can be found in Figure S1. The red shift of the characteristic peak from 3439 to 3398 cm –1 manifests the formation of H-bonds between the hydroxyl groups in TA and the ether groups in PEO.…”

Section: Resultsmentioning

confidence: 99%

Fabricating 3D Moisture- and NIR Light-Responsive Actuators by a One-Step Gradient Stress-Relaxation Process

Hu,

Jiang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Polymeric materials that can actuate under the stimulation of environmental signals have attracted considerable attention in fields including artificial muscles, soft robotics, implantable devices, etc. To date, the improvement of shapechanging flexibility is mainly limited by their unchangeable shapes and structural and compositional distributions. In this work, we report a one-step treatment process to convert 2D poly(ethylene oxide)/sodium alginate/tannic acid thin films into 3D-shaped moisture-and NIR light-responsive actuators. Spatial surface wetting of the film leads to the release of residual stress generated in film formation in a gradient manner, which drives the wetted regions to bidirectionally bend. By controlling the position and bending amplitude of the wetted regions, designated 3D shapes can be obtained. Moreover, Fe 3+ ions in the aqueous solution used for surface wetting can coordinate with carboxylate groups in sodium alginate chains to form a gradient cross-linking network. This gradient network can not only stabilize the resulting 3D shape but also render the film with moisture-responsive morphing behaviors. Fe 3+ ions can also self-assemble with tannic acid molecules to form photothermal aggregates, making the film responsive to NIR light. We further show that films with versatile 3D shapes and different modes of deformation can be fabricated by a one-step treatment process. This strategy is convenient and extendable to develop 3Dshaped polymer actuators with flexible shape-changing behaviors.

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“…However, certain limitations and challenges must be considered, such as difficulties in scaling up the use of high TA content owing to the limited solubility and rapid crosslinking of TA in aqueous systems with polymers. 192 The long-term stability of hydrogels and their strain-sensing performance may be affected by the interactions between TA and salt electrolytes, which should be studied in detail. 263 Most TA-based hydrogel strain sensors operate via piezoresistive mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…As a cross-linking molecule, TA can form H bonds with functional groups on other polymers such as silk, gelatin, CS, and PVA to enhance the mechanical properties of conductive hydrogels for strain sensors. 186–192 The –OH groups and benzene rings in the polyphenolic moieties can cross-link the gelatin polymer chains through H bonds and hydrophobic interactions (Fig. 14(a)), thereby improving the mechanical properties with increasing TA content in the hydrogel (Fig.…”

Section: Small Biomolecules For Hydrogel-based Strain Sensorsmentioning

confidence: 99%

“…This journal is © The Royal Society of Chemistry 2023 hydrogels for strain sensors. [186][187][188][189][190][191][192] The -OH groups and benzene rings in the polyphenolic moieties can cross-link the gelatin polymer chains through H bonds and hydrophobic interactions (Fig. 14(a)), thereby improving the mechanical properties with increasing TA content in the hydrogel (Fig.…”

Section: Zwitterionic Osmolytesmentioning

confidence: 99%

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Multifunctional small biomolecules as key building blocks in the development of hydrogel-based strain sensors

Zaidi¹,

Saeed²,

Heo³

et al. 2023

J. Mater. Chem. A

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Abundant tannic acid modified gelatin/sodium alginate biocomposite hydrogels with high toughness, antifreezing, antioxidant and antibacterial properties

Cited by 54 publications

References 46 publications

Injectable, Water-Reinforceable, and Antibacterial Tissue Adhesive with Underwater Bioadhesion Capability

Injectable, Water-Reinforceable, and Antibacterial Tissue Adhesive with Underwater Bioadhesion Capability

Fabricating 3D Moisture- and NIR Light-Responsive Actuators by a One-Step Gradient Stress-Relaxation Process

Multifunctional small biomolecules as key building blocks in the development of hydrogel-based strain sensors

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