ABVD (8 cycles) versus BEACOPP (4 escalated cycles ≥4 baseline): final results in stage III–IV low-risk Hodgkin lymphoma (IPS 0–2) of the LYSA H34 randomized trial

Mounier, Nicolas; Brice, Pauline; Bologna, Serge; Brière, Josette; Gaillard, Isabelle; Heczko, Marian; Gabarre, Jean; Casasnovas, Olivier; Jaubert, J.; Colin, Philippe; Delmer, Alain; Devidas, Alain; Bachy, Emmanuel; Nicolas‐Virelizier, Emmanuelle; Aoudjhane, A.; Humbrecht, Catherine; André, Marc; Carde, Patrice

doi:10.1093/annonc/mdu189

Cited by 100 publications

(78 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Оценка 5-летней ВБП в 4 рандомизи-рованных исследованиях показала статистически значимое преимущество на 12-18 % для интен-сифицированных программ (p = 0,003, p = 0,004, p = 0,008 и p = 0,038 соответственно) и на 4-7 % при оценке 5-летней ОВ [4,[19][20][21]. Эти данные подтверждены и в обобщающем метаанализе 14 рандомизированных исследований по лечению распространенных стадий ЛХ (ABVD vs ВЕАСОРР) [9].…”

Section: Discussionunclassified

First-Line Therapy for Patients with Advanced Hodgkin’s Lymphoma: Efficacy and Toxicity of Intensive ЕАСОРР-14 Program (NN Blokhin National Medical Cancer Research Center Data)

Демина¹,

Леонтьева²,

Tumyan³

et al. 2017

Клиническая онкогематология

View full text Add to dashboard Cite

Aim. To assess the efficacy and toxicity of intensive 6 courses EACOPP-14 treatment with or without radiotherapy (RT) for advanced stages of Hodgkin's lymphoma (HL). Materials & Methods. From November 2009 to February 2015, 95 patients with advanced stages of HL (IIX-IIE, III-IV) aged between 17 and 50 years (median 29 years) were selected for the participation in the protocol ЛХМосква1-3. The study population consisted of 46.3 % men and 53.7 % women. The results of the treatment were assessed in 91 patients who have received more than 2 courses of EACOPP-14. The follow up period was at least 3 months after the receiving the therapy. Consolidation RT with a total dose of 30 Gy for residual tumor lesions and/or initially large tumors was performed after the chemotherapy. Results. Complete remission was achieved in 82 (90.1 %) patients, partial remission in 2 (2.2 %), and the progression was observed in 7 (7.7 %) patients. The overall 4-year survival rate was 90.8 %, the progression-free survival was 88.2 %. The toxicity of the ЕАСОРР-14 program was slightly lower than that of 8 courses of ВЕАСОРРesc, and was comparable to the toxicity of other modifications of intensified ВЕАСОРР scheme. Hematological toxicity grade 3 and 4 was most commonly observed: leukopenia was observed after 64.9 % of courses, anemia - after 24 % of courses, thrombocytopenia - after 3.8 % of courses. The rate of infections did not singificantly differ and accounted for 24 %. The most frequent non-infectious complications were mucositis (21.1 %) and polyneuropathy (11.7 %). Complications resulted in the change of treatment in only 3 (3.01 %) of patients. The exclusion of bleomycine from the ЕАСОРР-14 program reduced the frequency of RT complications. Grade 3 pulmonitis developed in 4.5 % of cases, while radiation-induce pulmonary fibrosis verified by CT developed in 15.2 % of cases. The ЕАСОРР-14 6 courses program showed its high efficacy both with and without RT, high tolerance and the possibility of full administration for the majority of patients with the various stages of HL. Conclusion. Current research showed the efficacy of treatment without RT for patients with advanced stages of HL with negative PET results and small (< 2.5 cm) residual tumors after intensive ЕАСОРР-14 program. This approach allowed to avoid a number of late treatment complications.

show abstract

Section: Discussionunclassified

First-Line Therapy for Patients with Advanced Hodgkin’s Lymphoma: Efficacy and Toxicity of Intensive ЕАСОРР-14 Program (NN Blokhin National Medical Cancer Research Center Data)

Демина¹,

Леонтьева²,

Tumyan³

et al. 2017

Клиническая онкогематология

View full text Add to dashboard Cite

show abstract

“…[72][73][74][75] However, some of these studies were not sufficiently powered to determine differences in OS due to small patient numbers. The EORTC 20012 trial evaluated BEACOPP (4 cycles of escalated-dose and 4 cycles of standard-dose) and ABVD (8 cycles) in high-risk patients with stage III-IV disease and IPS ≥3 (274 patients in the BEACOPP arm and 275 patients in the ABVD arm).…”

Section: Stage Iii-ivmentioning

confidence: 99%

Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology

Hoppe¹,

Advani²,

Ai³

et al. 2017

J Natl Compr Canc Netw

View full text Add to dashboard Cite

OverviewHodgkin lymphoma (HL) is an uncommon malignancy involving lymph nodes and the lymphatic system. Most patients are diagnosed between 15 and 30 years of age, followed by another peak in adults aged ≥55 years. In 2017, an estimated 8,260 people will be diagnosed with HL in the United States and 1,070 will die of the disease. AbstractThis portion of the NCCN Guidelines for Hodgkin lymphoma (HL) focuses on the management of classical HL. Current management of classical HL involves initial treatment with chemotherapy or combined modality therapy followed by restaging with PET/CT to assess treatment response using the Deauville criteria (5-point scale). The introduction of less toxic and more effective regimens has significantly advanced HL cure rates. However, long-term follow-up after completion of treatment is essential to determine potential long-term effects. Please NoteThe NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines These guidelines are also available on the Internet. For the latest update, visit NCCN.org.

show abstract

“…Innym połączeniem mającym zastosowanie w leczeniu tego typu nowotworu jest BEACOPP (bleomycyna, etopozyd, doksorubicyna, cyklofosfamid, winkrystyna, prokarbazyna, prednizon). W badaniu porównującym te dwa schematy leczenia wyniki wskazywały na lepszy pięcioletni czas przeżycia wolnego od progresji w przypadku stosowania zwiększonych dawek BEACOPP w porównaniu do ABVD, jednak ten pierwszy schemat wiązał się również z większym ryzykiem powikłań (13). Winkrystyna, oprócz leczenia ziarnicy złośliwej (na przykład jako składnik BEACOPP), jest stosowana w terapii ostrej białaczki limfoblastycznej (ALL), chłoniaków nieziarniczych, mięsaków i wielu innych rodzajów nowotworów oraz niezłośliwych zaburzeń hematologicznych (10,12,13).…”

Section: Wprowadzenieunclassified

Substancje pochodzenia roślinnego w terapii nowotworów

Gurgul¹,

Lityń́ska²

2017

View full text Add to dashboard Cite

ABVD (8 cycles) versus BEACOPP (4 escalated cycles ≥4 baseline): final results in stage III–IV low-risk Hodgkin lymphoma (IPS 0–2) of the LYSA H34 randomized trial

Cited by 100 publications

References 18 publications

First-Line Therapy for Patients with Advanced Hodgkin’s Lymphoma: Efficacy and Toxicity of Intensive ЕАСОРР-14 Program (NN Blokhin National Medical Cancer Research Center Data)

First-Line Therapy for Patients with Advanced Hodgkin’s Lymphoma: Efficacy and Toxicity of Intensive ЕАСОРР-14 Program (NN Blokhin National Medical Cancer Research Center Data)

Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology

Substancje pochodzenia roślinnego w terapii nowotworów

Contact Info

Product

Resources

About