Acacetin and Chrysoeriol: A Short Review of the Chemistry, Plant Sources, Bioactivities and Structure-Activity Relationships of these Methylated Flavones

Abstract

relationship of polymethoxylated flavones such as nobiletin and tangeretin showed a correlation between the number/position of methoxy group and their antiproliferative activity. 10,11 In this short review, the chemistry, plant sources, bioactivities and structure-activity relationships of acacetin (ACT) and chrysoeriol (CSE) are reviewed. These methylated flavones are found in many plant species and have been reported to exhibit diverse pharmacological properties notably anti-cancer activities. To date, only ACT has been reviewed, 12,13 while CSE has not been reviewed. Chemistry Acacetin ACT (5,7-dihydroxy-4'-methoxyflavone) is a natural methylated flavone. 12 Its molecular formula is C16H12O5 and its molecular weight is 284 g/mol. Being a flavone, ACT has a C2-C3 double bond, a 4carbonyl group but lacks the C3 hydroxyl group of ring C (Figure 1).

Tricetin and Tricin: An Overview of the Chemistry, Sources, Contents, and Pharmacological Properties of these Flavones

“…Methylation also enhances their properties such as anticancer, immuno-modulation and antioxidant activities 6,7 . Examples of methylated flavones with one methoxy group are diosmetin, acacetin and chrysoeriol 8,9 . Examples of Polymethylated Flavones (PMFs) with five and six methoxy (OCH 3 ) groups are tangeretin and nobiletin, respectively 10 .…”