Academy of Nutrition and Dietetics Nutrition Research Network: The Saqmolo' Project Rationale and Study Protocol for a Randomized Controlled Trial Examining the Influence of Daily Complementary Feeding of Eggs on Infant Development and Growth in Guatemala

Wallace, Taylor C.; Rohloff, Peter; Jimenez, Elizabeth Yakes; Proaño, Gabriela V.; Montenegro-Bethancourt, Gabriela; McCabe, George P.; Steiber, Alison

doi:10.1016/j.jand.2021.03.015

Cited by 5 publications

(4 citation statements)

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“…Maya Health Alliance works alongside Indigenous communities to improve access to healthcare as well as leading clinical trial and observational studies on complementary feeding, stunting, dietary quality and early child development. 23–25 …”

Section: Methodsmentioning

confidence: 99%

“…In this project, we will work in rural Guatemala in collaboration with Maya Health Alliance, the lead local institution, which facilitates primary care and research in service of the local Indigenous Maya population. Maya Health Alliance works alongside Indigenous communities to improve access to healthcare as well as leading clinical trial and observational studies on complementary feeding, stunting, dietary quality and early child development 23–25…”

Section: Methodsmentioning

confidence: 99%

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Assessment of aflatoxin exposure, growth faltering and the gut microbiome among children in rural Guatemala: protocol for an observational prospective cohort and bioreactor simulations

Cheng

Glesener

Montenegro³

et al. 2023

bmjpo

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IntroductionAflatoxin B1 (AFB1) is a carcinogen produced byAspergillus flavusandAspergillus parasiticuswhich grow on maize. Given the high prevalence of child stunting (ie, impaired growth) and other nutritional disorders in low-income and middle-income countries, where maize is consumed, the role of aflatoxin exposure may be significant. Observational reports have demonstrated associations between aflatoxin exposure and impaired child growth; however, most have been cross-sectional and have not assessed seasonal variations in aflatoxin, food preparation and dynamic changes in growth. Biological mechanistic data on how aflatoxin may exert an impact on child growth is missing. This study incorporates a prospective cohort of children from rural Guatemala to assess (1) temporal associations between aflatoxin exposure and child growth and (2) possible mediation of the gut microbiome among aflatoxin exposure, inflammation and child growth.Methods and analysisWe will prospectively evaluate aflatoxin exposure and height-for-age difference trajectories for 18 months in a cohort of 185 children aged 6–9 months at enrolment. We will assess aflatoxin exposure levels and biomarkers of gut and systemic inflammation. We will examine the faecal microbiome of each child and identify key species and metabolic pathways for differing AFB1 exposure levels and child growth trajectories. In parallel, we will use bioreactors, inoculated with faeces, to investigate the response of the gut microbiome to varying levels of AFB1 exposure. We will monitor key microbial metabolites and AFB1 biotransformation products to study nutrient metabolism and the impact of the gut microbiome on aflatoxin detoxification/metabolism. Finally, we will use path analysis to summarise the effect of aflatoxin exposure and the gut microbiome on child growth.Ethics and disseminationEthics approval was obtained from Arizona State University Institutional Review Board (IRB; STUDY00016799) and Wuqu’ Kawoq/Maya Health Alliance IRB (WK-2022-003). Findings will be disseminated in scientific presentations and peer-reviewed publications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Assessment of aflatoxin exposure, growth faltering and the gut microbiome among children in rural Guatemala: protocol for an observational prospective cohort and bioreactor simulations

Cheng

Glesener

Montenegro³

et al. 2023

bmjpo

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“…Majene Society own tradition and knowledge typical in selecting, processing, and consuming food that can give sufficient nutrition during the delivery period food companion For growth and development optimal child. 12 Utilization wisdom local in provision of MP-ASI can be an effective strategy in prevention of stunting in the region this. This signify that appetite Eat everyone can different and can also be the same.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Giving of Mp-Asi Through Food Based on Majene's Local Wisdom for Stunting Prevention

Evawati,

Jafar,

Hidayanty

et al. 2024

Pharmacogn J.

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Background: Majene Society own tradition and knowledge typical in selecting, processing, and consuming food. Use food local can maintain diversity food and culture local. Food local has proven effective for growth baby optimally. Goals: With do comprehensive analysis to provision of MP-ASI through foodbased wisdom local Majene, expected can an effective and sustainable stunting prevention program was developed. Method: Method research used is study qualitative with design phenomenology. Informant in study This are 103 Baduta mothers who are exclusively breastfed, and live in rural districts Pamboang and District Tameroddo. Data analyzed use content analysis through N-Vivo 12 app. Results: Food tree chief in Tameroddo is rice red Because rice red become plant lots of fields found and easy grows in mountainous areas. Meanwhile in the Coastal Region Pamboang Still consistent with rice white or yams. Typical vegetables is leaf moringa, Langurru ', and Lallere '. Government Regency Majene push planting leaf moringa in each home easy get and help in increase continuity food, savings cost, and independence food in Majene. Besides That, leaf moringa of course known known as " tree magic " because mark high nutrition. Majene Society own access and consumption vegetables langngurru ' and lallere ' are just that found in the area mountains Tameroddo. Usually leaf This used as plant medicine, but in this area made as processed vegetables with add mango sour. Side dish typical Majene known with called " Baupapi ". Habit consumption child given Eat with Fish sauce is considered Already enough , even often this fish sauce considered as replacement vegetables , though very easy found various the main fish species in the coastal area Pamboang . Known Pineapple in local language Majene as "Pandeng" is easiest fruit found Because grow with flourish in the yards House citizen. Findings food local the has content test nutrition and recipe test so that can used as the proper MP-ASI menu for given to baby for optimal growth. Conclusions and Suggestions: Important For ensure that kids get too consumption of fish or other protein sources as well as nutrition from vegetables and sources food other. Order child get appropriate nutrition through provision of adequate MP-ASI. Recommended to nanny , power health and government regency Majene to encourage provision of local MP-ASI with still notice mark appropriate nutrition , MP -ASI module as research output This can used as guidelines Proper provision of MP-ASI .

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“…The Saqmolo’ (i.e., “egg” in the Mayan language, Kaqchiquel) Project is an individually randomized, partially blinded, controlled comparative effectiveness trial to evaluate the influence of adding delivery of a single whole egg per day to local standard nutrition care (i.e., growth monitoring, medical care, deworming medication, multiple micronutrient powders for point‐of‐use food fortification, and individualized complementary and responsive feeding education for caregivers) for 6 months, compared with the local standard nutrition care package alone, on child development, growth, and diet quality measures in rural indigenous Maya infants aged 6–9 months at baseline ( N = 1200). The study is being implemented by Wuqu’ Kawoq – Maya Health Alliance (MHA) and the protocol has been published (Wallace et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the nutrient composition of eggs produced in the Guatemalan highlands during the wet and dry seasons

Wallace,

Montenegro‐Bethancourt,

Rohloff

et al. 2023

Food Science & Nutrition

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The potential of chicken eggs as a nutritionally complete protein and source of key micronutrients during the first 1000 days post‐conception has been progressively recognized across the globe, particularly in resource‐poor settings. Fluctuation of egg nutrient content by season is relatively unknown, which may influence international food composition databases and outcomes in intervention studies using egg supplementation. To better interpret the findings of The Saqmolo' Project, we conducted comprehensive nutrient analyses on eggs produced during the wet and dry seasons in the highlands of central Guatemala. We randomly collected 36 shell eggs from a local farm during both seasons, hard‐boiled, and prepared them for transport to the United States, where they were pooled and assessed for their nutrient composition. Methods of the Association of Official Analytical Chemists, the American Oil Chemists Society, and the American Association of Cereal Chemists were utilized to determine total energy, moisture, ash, total protein, total fat, fatty acids, total carbohydrates, 12 vitamins, 11 minerals, and carotenoids, by season, in some instances with modifications. Differences in nutrient composition between de‐shelled hard‐boiled eggs collected between seasons were assessed using an analysis of variance (ANOVA) and Tukey's family error rate comparison test. Most nutrients in eggs produced in the highlands of central Guatemala differed negligibly (but statistically significantly) based on seasonality. Only vitamins A and E, folate, choline, and calcium fluctuated at clinically significant levels relative to the AI/RDA for infants 7–12 months. Total energy, protein, trans fatty acids, moisture, and vitamin D3 levels did not differ between seasons (p > .05). Further multi‐year sampling is needed to examine how seasonal variation affects the nutrient composition of eggs. These data may be used to supplement existing national and regional food composition databases.

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Academy of Nutrition and Dietetics Nutrition Research Network: The Saqmolo' Project Rationale and Study Protocol for a Randomized Controlled Trial Examining the Influence of Daily Complementary Feeding of Eggs on Infant Development and Growth in Guatemala

Cited by 5 publications

References 43 publications

Assessment of aflatoxin exposure, growth faltering and the gut microbiome among children in rural Guatemala: protocol for an observational prospective cohort and bioreactor simulations

Assessment of aflatoxin exposure, growth faltering and the gut microbiome among children in rural Guatemala: protocol for an observational prospective cohort and bioreactor simulations

Analysis of the Giving of Mp-Asi Through Food Based on Majene's Local Wisdom for Stunting Prevention

Comparison of the nutrient composition of eggs produced in the Guatemalan highlands during the wet and dry seasons

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