Acanthamoeba spp. como parásitos patógenos y oportunistas

Castrillón, Juan Camilo; Orozco, Lina P

doi:10.4067/s0716-10182013000200005

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…Species morphology might change depending on culture media conditions, resulting in variations in cyst morphology, an important feature for species identification. Furthermore, several studies have shown disagreements in the morphology of cysts from the same isolates, which implicates that morphological identification, alone, should not be used for species identification, requiring the use of molecular approaches (Khan 2006;Castrillón and Orozco 2013). Currently, molecular classification methods have been generated, generally classifying isolates based on the nuclear small subunit 18S ribosomal RNA whole gene sequence (Rns).…”

Section: Introductionmentioning

confidence: 99%

Genotype distribution of Acanthamoeba in keratitis: a systematic review

2021

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Acanthamoeba spp. are among the most worldwide prevalent protozoa. It is the causative agent of a disease known as Acanthamoeba keratitis, a painful and severe sight-threatening corneal infection that can lead to blindness. In recent years, the prevalence of Acanthamoeba keratitis has rapidly increased, growing its importance to human health. This systematic review aims to assess the distribution of Acanthamoeba sp. genotypes causing keratitis around the world, considering the sample collected type and the used identification method. Most of the cases were found in Asia and Europe. Not surprisingly, the T4 genotype was the most prevalent worldwide, followed by T3, T15, T11, and T5. Furthermore, the T4 genotype contains a higher number of species. Given the differences in pathology, susceptibility to treatment, and clinical outcome between distinct genotypes, it is essential to genotype isolates from Acanthamoeba keratitis cases to help to establish a better correlation between in vitro and in vivo activities, resulting in better drug therapies and successful treatment in cases of this important ocular infection.

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Section: Introductionmentioning

confidence: 99%

Genotype distribution of Acanthamoeba in keratitis: a systematic review

2021

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“…In humans, amoebic infections principally occur in immunocompromised patients, causing GAE or disseminated amoebic disease developing into encephalitis, meningitis, pneumonia, and dermatitis. In the described keratitis cases, the use of contact lenses has been described as the main predisposing factor and can occur in both immunocompromised and immunocompetent patients (5,6,13,16,24,28).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Microorganisms belonging to the genera Acanthamoeba, Naegleria and Balamuthia are free-living amoebae that cause important infections in human and animals (5,25,29). Acanthamoeba species have worldwide distribution and can be frequently found in soil, dust, air, fresh water and salt water, as well as cellular culture contaminants (5). Additionally, they can be found in other contaminated sources such as swimming pools, drinking water, ventilation systems, dialysis apparatus, hydrotherapy areas in hospitals, dental irrigation systems, bottled mineral water, distilled water bottles, insects, vegetables, and surgical instruments (6).…”

Section: Introductionmentioning

confidence: 99%

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Disseminated acanthamoebiasis in a horse

González¹,

Fresneda²,

Carvallo³

2020

BJVP

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Amoebic infections have been described in humans and animals, causing lesions in specific organs or as systemic infections. In both animals and humans, immunocompromised patients are predisposed to the infection. The present report described the macroscopic and histologic findings in a Quarter horse filly who presented with a systemic infection caused by Acanthamoeba spp. that was characterized by multinodular lesions in lung, kidney, heart, submandibular lymph node, and lip. Histopathology revealed dense inflammatory infiltrates composed of neutrophils, histiocytes, occasional multinucleated giant cells, and numerous intralesional trophozoites. Immunohistochemistry was positive for Acanthamoeba spp trophozoites in lungs, kidneys, heart, submandibular lymph node, and lip. No predisposing conditions were identified.

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“…Por su gran (1) ubicuidad no es sorprendente que entren en contacto con los seres humanos y causar infecciones . Entre (2)(3)(4) las especies más comunes capaces de provocar afectación ocular provocando infecciones corneales se pueden mencionar a A. castellanii, A. polyphaga, A. hatchetti, A. culbertsoni, A. rhysodes, A. griffini, A. (5) quina A. lugdunensis y .…”

Section: Launclassified

Status of the diagnosis of Amebic Keratitis in Paraguay

Abente¹,

Franco²,

Samudio³

et al. 2019

Rev. salud publica Parag.

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Free-living amoeba (FLA) exist widely distributed in nature, where the genus Acanthamoeba is the most isolated in various soil, air and water environments and has been associated with diseases in humans. Its ability to live in adverse environments is due to the low demand for food it has and that in its biological cycle has a cyst-shaped stage, which makes it very resistant. Man becoming his host, can cause infections in the central nervous system, disseminated infections in the skin and lungs, and keratitis, becoming a very important etiological agent of human pathologies. This review addresses characteristics that are known from Acanthamoeba spp., such as its biology, pathogenesis and human defense mechanisms against A c a n t h a m o e b a i n f e c t i o n ; I n a d d i t i o n , t h e microbiological and molecular diagnosis, which is a tool that has improved with the advancement of technology and are essential for timely identification and thus achieve a good clinical and therapeutic intervention. Finally, we present the current situation in Paraguay regarding the few existing clinical reports and the diagnostic methods available.

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Acanthamoeba spp. como parásitos patógenos y oportunistas

Cited by 16 publications

References 40 publications

Genotype distribution of Acanthamoeba in keratitis: a systematic review

Genotype distribution of Acanthamoeba in keratitis: a systematic review

Disseminated acanthamoebiasis in a horse

Status of the diagnosis of Amebic Keratitis in Paraguay

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