Ação do extrato de Jatropha gossypiifolia L. (pião roxo) na cicatrização de anastomose colônica: estudo experimental em ratos

Servin, Santiago Cirilo Nogueira; Torres, Orlando Jorge Martins; Matias, Jorge Eduardo Fouto; Agulham, Miguel Ângelo; Carvalho, Fábio Augusto de; Lemos, Ricardo; Soares, Emerson Wander Silva; Soltoski, Paulo Roberto; Freitas, Alexandre Coutinho Teixeira de

doi:10.1590/s0102-86502006000900012

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…However, according to these authors, on the seventh day of the experiment, there was a decrease in the action of the extract, suggesting that the extract, in this experiment, was less active in later stages of healing process [122]. A plausible hypothesis, not raised by the authors, could be the fact that the extract was administered in a single dose, which may not have been sufficient to maintain the effect throughout the time of the experiment.…”

Section: Pharmacological Activitiesmentioning

confidence: 84%

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Félix-Silva

Giordani

Silva-Jr

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. However, critical reviews discussing emphatically its medicinal value are missing. This review aims to provide an up-to-date overview of the traditional uses, as well as the phytochemistry, pharmacology, and toxicity data of J. gossypiifolia species, in view of discussing its medicinal value and potential application in complementary and alternative medicine. Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, and anticancer agents, among others, supporting some of its popular uses. No clinical trial has been detected to date. Further studies are necessary to assay important folk uses, as well as to find new bioactive molecules with pharmacological relevance based on the popular claims. Toxicological studies associated with phytochemical analysis are important to understand the eventual toxic effects that could reduce its medicinal value. The present review provides insights for future research aiming for both ethnopharmacological validation of its popular use and its exploration as a new source of herbal drugs and/or bioactive natural products.

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Section: Pharmacological Activitiesmentioning

confidence: 84%

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Félix-Silva

Giordani

Silva-Jr

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…There were no studies reporting the content of total phenolic compounds and flavonoids in the S. hispida. The clot formation and the presence of fibrin and inflammatory exudate are important for the occurrence of coaptation of the wounds' edges, the intersection of fibronectin, providing a provisional matrix (fibrin crust), so that the fibroblasts, endothelial cells and keratinocytes can enter the wound (Mandelbaum et al, 2003;Servin et al, 2006). Clinically, the healing process is characterized by four biologically distinct phases; the inflammatory, the proliferative and the remodeling phase.…”

Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5) were G1 (Saline); G2 (crude methanol plant extract 2% + Carbopol Gel 98%); G3 (crude methanol plant extract 2% + lanolin/vaseline) and G4 (laser). The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP) 660 nm in the model used.Keywords: laser therapy, tissue repair, inflammatory cells, medicinal plants. Potencial cicatrizante da pomada de Sebastiania hispida (Mart.) Pax (Euphorbiaceae) comparado ao laser de baixa potência ResumoA cicatrização deficiente representa uma complicação grave em algumas patologias e o uso de extratos de plantas tem demonstrado melhora no processo de reparação tecidual. O objetivo deste estudo foi avaliar o potencial cicatrizante da pomada de Sebastiania hispida comparado ao Laser Indio Phosphide-Gallium-Aluminum (InGaAlP) em feridas cutâneas induzidas cirurgicamente em ratos e realizar analise fitoquímica. A análise fitoquímica foi via clássica e por CLAE. O experimento foi desenvolvido com 80 ratos (200-250 g), divididos aleatoriamente em quatro grupos (n = 5): G1 (salina); G2 (extrato bruto metanólico 2% + Carbopol Gel 98%); G3 (extrato bruto metanólico 2% + lanolina/ vaselina) e G4 (laser). Após a tricotomia da região dorsal realizou uma excisão linear, medindo 2 cm × 1 cm (epiderme e derme), expondo a fáscia muscular. Em sequência os tratamentos e o monitoramento do processo de cicatrização das feridas cirúrgicas ocorreu nos tempos de: 3, 7, 14 e até 21 dias após a excisão. Os parâmetros histológicos avaliadosBraz.

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“…O extrato alcoólico foi testato na cicatrização de anastomose colônica em ratos. Embora tenha apresentado um fraco efeito no estágio final de cicatrização, este mostrou um resultado favorável na diminuição do processo de inflamação (SERVIN, et al, 2006).…”

Section: Jatropha Gossypifoliaunclassified

FITOQUÍMICA E ATIVIDADES BIOLÓGICAS DO GÊNERO Jatropha: MINI-REVISÃO

Hirota¹,

Trevisan²,

Dias³

et al. 2010

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Ação do extrato de Jatropha gossypiifolia L. (pião roxo) na cicatrização de anastomose colônica: estudo experimental em ratos

Cited by 14 publications

References 11 publications

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

FITOQUÍMICA E ATIVIDADES BIOLÓGICAS DO GÊNERO Jatropha: MINI-REVISÃO

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