Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits

Abstract

2.1. Animals, anesthesia, and surgical procedure Animals were sedated with an intramuscular injection of 40 mg/kg ketamine and 4 mg/kg xylazine. Induction to anesthesia was achieved by an intravenous application of 1% propofol in the ear vein through a 24-G cannula. Epidurally 2% lidocaine was administered in a dose of 1 mL/5 kg body weight. General anesthesia was maintained by breathing a mixture of oxygen and isoflurane applied through a face mask. Antibiotic

Therapeutic Advances in Tendinopathy Quantified Microscopically Using Bonar Score, with a Special Reference to PRP Therapy—A Systematic Review of Experimental Studies

“…In three cases, there were two investigators [16,37,48] (Table 2). However, in eight studies, there were no data concerning the number of microscopic examiners [34,[38][39][40][50][51][52][53].…”

“…The standard staining protocol was based on hematoxylin and eosin, while the most popular additional staining method was Alcian Blue [1,[34][35][36][37][38][39][40][41][43][44][45][46][47]49] The second most frequent method was Masson Trichrome [16,34,36,[38][39][40][42][43][44]47,50]. Other staining methods, such as Picrosirius red Verhoeff van Gieso, Gridley method, Gomori method, Safranin, Toluidine Blue, and Alizarin Red, were rather rare [37,44].…”

“…Most of the collected studies included an assessment of the tendons' histopathology based on the classical Bonar score with four variables [1,16,34,36,[38][39][40][41][42][43][44][46][47][48][49][50][51][52][53]. However, a few authors aimed to modify the classical assumptions of the scoring system in order to improve the diagnostics and microscopic evaluation.…”